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Salt-dependent renal effects of an angiotensin II antagonist in healthy subjects
- Source :
- Hypertension. 22:339-347
- Publication Year :
- 1993
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 1993.
-
Abstract
- This study was designed to evaluate in healthy volunteers the renal hemodynamic and tubular effects of the orally active angiotensin II receptor antagonist losartan (DuP 753 or MK 954). Losartan or a placebo was administered to 23 subjects maintained on a high-sodium (200 mmol/d) or a low-sodium (50 mmol/d) diet in a randomized, double-blind, crossover study. The two 6-day diet periods were separated by a 5-day washout period. On day 6, the subjects were water loaded, and blood pressure, renal hemodynamics, and urinary electrolyte excretion were measured for 6 hours after a single 100-mg oral dose of losartan (n = 16) or placebo (n = 7). Losartan induced no significant changes in blood pressure, glomerular filtration rate, or renal blood flow in these water-loaded subjects, whatever the sodium diet. In subjects on a low-salt diet, losartan markedly increased urinary sodium excretion from 115 +/- 9 to 207 +/- 21 mumol/min (P < .05). The fractional excretion of endogenous lithium was unchanged, suggesting no effect of losartan on the early proximal tubule in our experimental conditions. Losartan also increased urine flow rate (from 10.5 +/- 0.4 to 13.1 +/- 0.6 mL/min, P < .05); urinary potassium excretion (from 117 +/- 6.9 to 155 +/- 11 mumol/min); and the excretion of chloride, magnesium, calcium, and phosphate. In subjects on a high-salt diet, similar effects of losartan were observed, but the changes induced by the angiotensin II antagonist did not reach statistical significance. In addition, losartan demonstrated significant uricosuric properties with both sodium diets.(ABSTRACT TRUNCATED AT 250 WORDS)
- Subjects :
- Adult
Male
medicine.medical_specialty
Uricosuric
Tetrazoles
Renal function
Blood Pressure
Angiotensin II receptor antagonist
Lithium
Urine
Kidney
Losartan
Renal Circulation
Excretion
Electrolytes
Urine flow rate
Double-Blind Method
Internal medicine
Renin
Internal Medicine
medicine
Humans
Aldosterone
Chemistry
Angiotensin II
Biphenyl Compounds
Hemodynamics
Imidazoles
Sodium, Dietary
Uric Acid
Endocrinology
Renal blood flow
Glomerular Filtration Rate
medicine.drug
Subjects
Details
- ISSN :
- 15244563 and 0194911X
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Hypertension
- Accession number :
- edsair.doi.dedup.....46aad8d3b9d1230e6247b811f791e6b8