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Genetic structure of phenotypic robustness in the collaborative cross mouse diallel panel
- Source :
- CONICET Digital (CONICET), Consejo Nacional de Investigaciones Científicas y Técnicas, instacron:CONICET
- Publication Year :
- 2016
- Publisher :
- Blackwell Publishing, 2016.
-
Abstract
- Developmental stability and canalization describe the ability of developmental systems to minimize phenotypic variation in the face of stochastic micro-environmental effects, genetic variation and environmental influences. Canalization is the ability to minimize the effects of genetic or environmental effects, whereas developmental stability is the ability to minimize the effects of micro-environmental effects within individuals. Despite much attention, the mechanisms that underlie these two components of phenotypic robustness remain unknown. We investigated the genetic structure of phenotypic robustness in the collaborative cross (CC) mouse reference population. We analysed the magnitude of fluctuating asymmetry (FA) and among-individual variation of cranial shape in reciprocal crosses among the eight parental strains, using geometric morphometrics and a diallel analysis based on a Bayesian approach. Significant differences among genotypes were found for both measures, although they were poorly correlated at the level of individuals. An overall positive effect of inbreeding was found for both components of variation. The strain CAST/EiJ exerted a positive additive effect on FA and, to a lesser extent, among-individual variance. Sex- and other strain-specific effects were not significant. Neither FA nor among-individual variation was associated with phenotypic extremeness. Our results support the existence of genetic variation for both developmental stability and canalization. This finding is important because robustness is a key feature of developmental systems. Our finding that robustness is not related to phenotypic extremeness is consistent with theoretical work that suggests that its relationship to stabilizing selection is not straightforward. Fil: Gonzalez, Paula Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - CONICET - La Plata. Instituto de Genética Veterinaria Ing. Fernando Noel Dulout; Argentina Fil: Pavlicev, Mihaela. Cincinnati Children's Hospital Medical Center ; Estados Unidos Fil: Mitteroecker, Philipp. Universidad de Viena; Austria Fil: Pardo Manuel de Villena, Fernando. No especifica; Fil: Spritz, Richard. University of Colorado; Estados Unidos Fil: Marcucio, Ralph. University of California; Estados Unidos Fil: Hallgrimsson, Benedikt. University of Calgary; Canadá
- Subjects :
- 0301 basic medicine
GEOMETRIC MORPHOMETRICS
Genotype
Genetic Structures
HETEROZYGOSITY
Otras Ciencias Biológicas
Biology
Fluctuating asymmetry
Article
Diallel cross
purl.org/becyt/ford/1 [https]
Ciencias Biológicas
03 medical and health sciences
Bayes' theorem
Mice
Genetic variation
Animals
Inbreeding
Stabilizing selection
purl.org/becyt/ford/1.6 [https]
Ecology, Evolution, Behavior and Systematics
Genetics
CANALIZATION
DEVELOPMENTAL STABILITY
Robustness (evolution)
Genetic Variation
Bayes Theorem
030104 developmental biology
Phenotype
Evolutionary biology
Genetic structure
SKULL
CIENCIAS NATURALES Y EXACTAS
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- CONICET Digital (CONICET), Consejo Nacional de Investigaciones Científicas y Técnicas, instacron:CONICET
- Accession number :
- edsair.doi.dedup.....46b10293e38a016756ef7b2008c7d6c1