A new bis-gamma-pyrone polypropionate of onchidiol family from marine pulmonate mollusk Onchidium sp

Authors :: Xia-Juan Huan
Li-Gong Yao
Ernesto Mollo
Wan-Xiang Cui
Xu-Wen Li
Yue-Wei Guo
Margherita Gavagnin
Ze-Hong Miao
Song-Wei Li
Source :: Natural product research, 34 (2020): 1971–1976. doi:10.1080/14786419.2019.1569010, info:cnr-pdr/source/autori:Li S.-W.; Cui W.-X.; Huan X.-J.; Gavagnin M.; Mollo E.; Miao Z.-H.; Yao L.-G.; Li X.-W.; Guo Y.-W./titolo:A new bis-gamma-pyrone polypropionate of onchidiol family from marine pulmonate mollusk Onchidium sp/doi:10.1080%2F14786419.2019.1569010/rivista:Natural product research (Print)/anno:2020/pagina_da:1971/pagina_a:1976/intervallo_pagine:1971–1976/volume:34
Publication Year :: 2020
Publisher :: Taylor & Francis Health Sciences, Abingdon (4 Park Square, Milton Park, Abingdon, Oxon OX14 4RN) , Regno Unito, 2020.
Abstract: A new bis-gamma-pyrone polypropionate, 4,16-di-epi-onchidiol (1), along with three known related compounds (2-4) were isolated from the marine pulmonate mollusk Onchidium sp. The structure of compound 1 was elucidated by extensive spectroscopic analysis and by comparison the NMR data with its stereoisomers 2-4, whereas its absolute configuration was determined by the combination of X-ray diffraction analysis and TDDFT-ECD calculation. In bioassay, the isolated compounds exhibited broad cytotoxicity against several cancer cell lines with IC50 values ranging from 24.6 to 88.5?M.

Language :: English
Database :: OpenAIRE
Journal :: Natural product research, 34 (2020): 1971–1976. doi:10.1080/14786419.2019.1569010, info:cnr-pdr/source/autori:Li S.-W.; Cui W.-X.; Huan X.-J.; Gavagnin M.; Mollo E.; Miao Z.-H.; Yao L.-G.; Li X.-W.; Guo Y.-W./titolo:A new bis-gamma-pyrone polypropionate of onchidiol family from marine pulmonate mollusk Onchidium sp/doi:10.1080%2F14786419.2019.1569010/rivista:Natural product research (Print)/anno:2020/pagina_da:1971/pagina_a:1976/intervallo_pagine:1971–1976/volume:34
Accession number :: edsair.doi.dedup.....46b1ea60e5149ec52788fec70f13c94f
Full Text :: https://doi.org/10.1080/14786419.2019.1569010

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