Back to Search
Start Over
Long-Term Incidence and Growth of Chorioretinal Atrophy in Patients with Polypoidal Choroidal Vasculopathy
- Source :
- Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde. 243(2)
- Publication Year :
- 2019
-
Abstract
- Purpose: To investigate the long-term incidence and growth rate of chorioretinal atrophy (CRA) in patients with polypoidal choroidal vasculopathy (PCV) and determine the associated risk factors. Methods: The medical records of 88 patients with unilateral symptomatic PCV who received anti-vascular endothelial growth factor (anti-VEGF) injections with or without photodynamic therapy (PDT) were analyzed retrospectively. Near-infrared fundus imaging and spectral domain optical coherence tomography were used to measure the CRA area and growth rate. Kaplan-Meier survival analysis was performed to estimate the CRA incidence. Logistic and linear regression analyses were used to investigate risk factors (e.g., age, frequency of abnormal OCT findings, PDT history, total injection number, and choroidal thickness) associated with the CRA incidence and growth rate, respectively. Results: The overall CRA incidence was 40.8% at 5 years. The absence of subretinal fluid, the presence of intraretinal fluid, and a thin choroid were significant risk factors for CRA occurrence with a history of PDT. Overall 5-year CRA growth rate was 0.69 mm2/year. Faster CRA growth was significantly related to the presence of subretinal hyperreflective material and thin choroid. PDT history was not significantly related to CRA growth. Conclusions: Thin choroid may be a significant risk factor for long-term development and growth of CRA in eyes with PCV. Intraretinal fluid seems to promote the development of CRA, while subretinal fluid seems to be associated with CRA prevention. The history of PDT was significantly related to the occurrence of CRA, but not to the growth rate of CRA.
- Subjects :
- Male
Vascular Endothelial Growth Factor A
medicine.medical_specialty
Time Factors
genetic structures
Fundus Oculi
medicine.medical_treatment
Visual Acuity
Fundus (eye)
01 natural sciences
Retina
03 medical and health sciences
0302 clinical medicine
Polyps
Ophthalmology
Republic of Korea
medicine
Humans
In patient
Significant risk
0101 mathematics
Fluorescein Angiography
Survival analysis
Aged
Retrospective Studies
business.industry
Choroid
Incidence (epidemiology)
Growth factor
Incidence
010102 general mathematics
Chorioretinal atrophy
General Medicine
Choroid Diseases
eye diseases
Sensory Systems
medicine.anatomical_structure
030221 ophthalmology & optometry
Female
sense organs
Atrophy
business
Tomography, Optical Coherence
Follow-Up Studies
Subjects
Details
- ISSN :
- 14230267
- Volume :
- 243
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde
- Accession number :
- edsair.doi.dedup.....46b958f78cf2306bb0f05af45e8f3b2d