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Supplementary Figure 2 from Accessory Cells of the Microenvironment Protect Multiple Myeloma from T-Cell Cytotoxicity through Cell Adhesion-Mediated Immune Resistance

Authors :
Tuna Mutis
Constantine S. Mitsiades
Anton C. Martens
Henk M. Lokhorst
Jana Jakubikova
Douglas W. McMillin
Richard W.J. Groen
Huipin Yuan
Niels Bovenschen
Tineke Aarts-Riemens
Julie H. Huang
Monique C. Minnema
Niels W.C.J. van de Donk
Sanne J. de Haart
Publication Year :
2023
Publisher :
American Association for Cancer Research (AACR), 2023.

Abstract

Supplementary Figure 2 - PDF file 50K, Accessory cells protect MM cells from WT-1 specific CTLs. U266 cells were co-cultured with WT-1 specific T cells in presence and absence of different accessory cells. MM cell viability was determined 24h after addition of T cells by CS-BLI (A). Granzyme B production in the supernatant was determined by ELISA (B). Significance of inhibition of MM cell survival in the presence of accessory cells was tested by unpaired two tailed student's t test. *= p

Details

Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....46ba42399dcef8117d6a6c7791748a18
Full Text :
https://doi.org/10.1158/1078-0432.22450001