Back to Search
Start Over
High prevalence of thyroid hormone autoantibody and low rate of thyroid hormone detection interference
- Source :
- Journal of Clinical Laboratory Analysis
- Publication Year :
- 2021
- Publisher :
- John Wiley and Sons Inc., 2021.
-
Abstract
- Objective Thyroid hormone autoantibody (THAb) is a common antibody in autoimmune disease and can interfere with the detection of thyroid hormone (TH). There was no research reporting the prevalence of THAb in Chinese and the rate of THAb interfering with TH detection. Methods We collected 114 patients with autoimmune thyroid disease (AITD) (Hashimoto's thyroiditis, 57 cases; Graves’ disease, 57 cases), 106 patients with nonthyroid autoimmune diseases (NTAID), and 120 healthy subjects. According to the presence or absence of thyroid antibodies, patients with NTAID were divided into two groups: NTAID‐AITD and NTAID groups. Radioimmunoprecipitation technique was used to detect THAb in all subjects. TH was detected on Abbot and Roche platforms in patients with positive THAb. Results The prevalence of THAb was 22.8% in Hashimoto's thyroiditis and 45.6% in Graves’ disease. The prevalence of THAb in AITD group was lower than that in NTAID or NTAID‐AITD groups (34.2% vs. 61.5%, p = 0.014; 34.2% vs. 71.3%, p<br />We firstly investigated THAb in Chinese patients, and we found the prevalence of THAb in AITD patients was lower than that in NTAID patients. Although THAb has a high frequency in various autoimmune diseases, the rate of THAb interfering with thyroid hormone detection was only 9.18%.
- Subjects :
- Microbiology (medical)
Adult
Male
medicine.medical_specialty
endocrine system
Radioimmunoprecipitation Assay
Thyroid Hormones
endocrine system diseases
Clinical Biochemistry
interference
Disease
Hashimoto Disease
Gastroenterology
Thyroiditis
nonthyroid autoimmune diseases
Internal medicine
medicine
Prevalence
Immunology and Allergy
Humans
Research Articles
Autoantibodies
Autoimmune disease
biology
business.industry
Biochemistry (medical)
Thyroid
Public Health, Environmental and Occupational Health
Autoantibody
Hematology
thyroid hormone autoantibody
Middle Aged
medicine.disease
Anti-thyroid autoantibodies
Graves Disease
Medical Laboratory Technology
medicine.anatomical_structure
biology.protein
Female
Antibody
autoimmune thyroid disease
business
Hormone
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 10982825 and 08878013
- Volume :
- 36
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Laboratory Analysis
- Accession number :
- edsair.doi.dedup.....46be673cd44d4a722c255a3e34d975c2