Back to Search
Start Over
PI16 is expressed by a subset of human memory Treg with enhanced migration to CCL17 and CCL20
- Publication Year :
- 2012
- Publisher :
- US : Academic Press, 2012.
-
Abstract
- The peptidase inhibitor PI16 was shown previously by microarray analysis to be over-expressed by CD4-positive/CD25-positive Treg compared with CD4-positive/CD25-negative Th cells. Using a monoclonal antibody to the human PI16 protein, we found that PI16-positive Treg have a memory (CD45RO-positive) phenotype and express higher levels of FOXP3 than PI16-negative Treg. PI16-positive Treg are functional in suppressor assays . in vitro with potency similar to PI16-negative Treg. Further phenotyping of the PI16-positive Treg revealed that the chemokine receptors CCR4 and CCR6 are expressed by more of the PI16-positive/CD45RO-positive Treg compared with PI16-negative/CD45RO-positive Treg or Th cells. PI16-positive Treg showed enhanced . in vitro migration towards the inflammatory chemokines CCL17 and CCL20, suggesting they can migrate to sites of inflammation. We conclude that PI16 identifies a novel distinct subset of functional memory Treg which can migrate to sites of inflammation and regulate the pro-inflammatory response at those sites. Refereed/Peer-reviewed
- Subjects :
- Chemokine
Immunology
CCR4
Inflammation
chemical and pharmacologic phenomena
C-C chemokine receptor type 6
Biology
T-Lymphocytes, Regulatory
Chemokine receptor
Cell Movement
mental disorders
medicine
CCL17
Humans
Cell Proliferation
Glycoproteins
Chemokine CCL20
FOXP3
Forkhead Transcription Factors
hemic and immune systems
CCL20
Phenotype
biology.protein
Cytokines
Leukocyte Common Antigens
Chemokine CCL17
medicine.symptom
Carrier Proteins
Immunologic Memory
psychological phenomena and processes
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....46bfd43adca2abd863cb3b63ded2f41f