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Conductive Polymeric-Based Electroactive Scaffolds for Tissue Engineering Applications: Current Progress and Challenges from Biomaterials and Manufacturing Perspectives
- Source :
- International Journal of Molecular Sciences, International Journal of Molecular Sciences, Vol 22, Iss 11543, p 11543 (2021)
- Publication Year :
- 2021
-
Abstract
- The practice of combining external stimulation therapy alongside stimuli-responsive bio-scaffolds has shown massive potential for tissue engineering applications. One promising example is the combination of electrical stimulation (ES) and electroactive scaffolds because ES could enhance cell adhesion and proliferation as well as modulating cellular specialization. Even though electroactive scaffolds have the potential to revolutionize the field of tissue engineering due to their ability to distribute ES directly to the target tissues, the development of effective electroactive scaffolds with specific properties remains a major issue in their practical uses. Conductive polymers (CPs) offer ease of modification that allows for tailoring the scaffold’s various properties, making them an attractive option for conductive component in electroactive scaffolds. This review provides an up-to-date narrative of the progress of CPs-based electroactive scaffolds and the challenge of their use in various tissue engineering applications from biomaterials perspectives. The general issues with CP-based scaffolds relevant to its application as electroactive scaffolds were discussed, followed by a more specific discussion in their applications for specific tissues, including bone, nerve, skin, skeletal muscle and cardiac muscle scaffolds. Furthermore, this review also highlighted the importance of the manufacturing process relative to the scaffold’s performance, with particular emphasis on additive manufacturing, and various strategies to overcome the CPs’ limitations in the development of electroactive scaffolds.
- Subjects :
- skin
Scaffold
Materials science
QH301-705.5
cardiac
muscle
Polymers
Nanotechnology
Biocompatible Materials
Electric Stimulation Therapy
Review
nerve
bone
Catalysis
Inorganic Chemistry
Tissue engineering
Absorbable Implants
Materials Testing
Cell Adhesion
Humans
Biology (General)
Physical and Theoretical Chemistry
QD1-999
Molecular Biology
Spectroscopy
Cell Proliferation
Tissue Engineering
Tissue Scaffolds
Manufacturing process
Organic Chemistry
Electric Conductivity
General Medicine
Computer Science Applications
Biomechanical Phenomena
Chemistry
Organ Specificity
Printing, Three-Dimensional
electroactive scaffold
additive manufacturing
conductive polymers
Hydrophobic and Hydrophilic Interactions
Subjects
Details
- ISSN :
- 14220067
- Volume :
- 22
- Issue :
- 21
- Database :
- OpenAIRE
- Journal :
- International journal of molecular sciences
- Accession number :
- edsair.doi.dedup.....46c84ac6f7324672174745e08f35698c