Back to Search
Start Over
CpG-methylation-based risk score predicts progression in colorectal cancer
- Source :
- Epigenomics. 12:605-615
- Publication Year :
- 2020
- Publisher :
- Future Medicine Ltd, 2020.
-
Abstract
- Aim: To identify patients with colorectal cancer (CRC) who are at a truly higher risk of progression, which is key for individualized approaches to precision therapy. Materials & methods: We developed a predictor associated with progression-free interval (PFI) using The Cancer Genome Atlas CRC methylation data. Results: The risk score was associated with PFI in the whole cohort (p < 0.001). A nomogram consisting of the risk score and other significant clinical features was generated to predict the 3- and 5-year PFI in the whole set (area under the curve: 0.79 and 0.71, respectively). Conclusion: The risk score based on 23 DNA-methylation sites may serve as the basis for improved prediction of progression in patients with CRC in future clinical practice.
- Subjects :
- Male
Oncology
Cancer Research
medicine.medical_specialty
Colorectal cancer
Biology
Risk Factors
Internal medicine
Genetics
medicine
Humans
In patient
Framingham Risk Score
Area under the curve
DNA Methylation
Middle Aged
Models, Theoretical
Nomogram
Prognosis
medicine.disease
CpG site
Cohort
DNA methylation
Disease Progression
CpG Islands
Female
Colorectal Neoplasms
Subjects
Details
- ISSN :
- 1750192X and 17501911
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Epigenomics
- Accession number :
- edsair.doi.dedup.....46e206c157141a351bbd91119c872294