Androgen-driven COVID-19 infection – is testosterone an enemy or a friend?

“Androgen-driven COVID-19 pandemic theory” from Carlos Gustavo Wambier and coworkers [ 1 ], introduced the plausible role of androgen receptor for SARS-CoV-2 infection and proposed a theory why males seem to be more vulnerable to the disease and have higher mortality [ 6 ], which is very convincing. The physiological roles of TMPRSS2 are currently unknown, but its connection with the androgen receptor gains suspicions about the possible involvement in less good outcome of COVID-19 infection in men. Recently, a great deal of evidence has already suggested that a TMPRSS2...