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Growth Hormone Improves Nerve Regeneration, Muscle Re-innervation, and Functional Outcomes After Chronic Denervation Injury
- Source :
- Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019), Scientific Reports
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- This study investigates the efficacy of systemic growth hormone (GH) therapy in ameliorating the deleterious effects of chronic denervation (CD) injury on nerve regeneration and resulting motor function. Using a forelimb CD model, 4 groups of Lewis rats were examined (n = 8 per group): Group-1 (negative control) 8 weeks of median nerve CD followed by ulnar-to-median nerve transfer; Group-2 (experimental) 8 weeks of median nerve CD followed by ulnar-to-median nerve transfer and highly purified lyophilized pituitary porcine GH treatment (0.6 mg/day); Group-3 (positive control) immediate ulnar-to-median nerve transfer without CD; Group-4 (baseline) naïve controls. All animals underwent weekly grip strength testing and were sacrificed 14 weeks following nerve transfer for histomorphometric analysis of median nerve regeneration, flexor digitorum superficialis atrophy, and neuromuscular junction reinnervation. In comparison to untreated controls, GH-treated animals demonstrated enhanced median nerve regeneration as measured by axon density (p 2 vs 865.2 ± 48.33 µm2; p
- Subjects :
- Male
0301 basic medicine
medicine.medical_specialty
Swine
Neuromuscular Junction
lcsh:Medicine
Article
03 medical and health sciences
Grip strength
0302 clinical medicine
Atrophy
Peripheral Nerve Injuries
Internal medicine
medicine
Animals
Axon
Muscle, Skeletal
lcsh:Science
Muscle Denervation
Multidisciplinary
business.industry
lcsh:R
medicine.disease
Muscle atrophy
Median nerve
Nerve Regeneration
Muscular Atrophy
030104 developmental biology
Endocrinology
medicine.anatomical_structure
Rats, Inbred Lew
Growth Hormone
Nerve Transfer
lcsh:Q
medicine.symptom
business
030217 neurology & neurosurgery
Reinnervation
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....46f49b49493daae9261c083fbb0ecf76