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Evidence of altered membrane phospholipid metabolism in the anterior cingulate cortex and striatum of patients with bipolar disorder I: A multi-voxel 1H MRS study
- Source :
- Journal of Psychiatric Research. 81:48-55
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Background Previous proton magnetic resonance spectroscopy (1H MRS) studies have reported elevated glycerophosphocholine plus phosphocholine (GPC+PC) in the basal ganglia of patients with bipolar disorders (BD), which implicates an imbalance between synthesis and degradation activity of neuronal and glia membrane phospholipids (MPLs). However, the full extent of altered metabolites of MPLs in subareas within the basal ganglia, such as caudate and putamen, as well as anterior cingulate cortex (ACC) of BD patients is poorly understood. Methods Multi-voxel 1H MRS measurements were acquired in 50 type-one BD (BD-I) and 44 healthy controls (HC) on a 3-T MRI scanner. Four different anatomically defined voxels covering ACC, caudate and putamen were systematically extracted and quantified using LCModel. Group differences in absolute GPC+PC and other metabolites were tested with age and gender as covariates. Results BD-I patients had higher GPC+PC levels in the anterior-dorsal ACC (p = 0.037), caudate (p = 0.005) and putamen (p = 0.004) compared to HC. GPC+PC levels in the caudate were elevated most significantly in currently unmediated BD-I patients (p = 0.022) and were positively correlated with HAM-D scores (r = 0.51, p = 0.005). PCr+Cr and myo-inositol levels were also significantly higher in the caudate head (F(1,45) = 6.010, p = 0.018) of patients compared to HC. NAA and glutamate levels were not significantly different between BD-I and HC in these regions (p > 0.05). Conclusion The increased GPC+PC in BD-I patients may reflect an imbalance in the MPL metabolism. Caudate GPC+PC levels may be a potential biomarker for depressive symptoms in BD.
- Subjects :
- Adult
Male
medicine.medical_specialty
Bipolar Disorder
Proton Magnetic Resonance Spectroscopy
Phospholipid
Glutamic Acid
Striatum
Gyrus Cinguli
Young Adult
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
Basal ganglia
Humans
Medicine
Choline
Phospholipids
Biological Psychiatry
Anterior cingulate cortex
Aged
Phosphocholine
Psychiatric Status Rating Scales
business.industry
Putamen
Glutamate receptor
Middle Aged
Creatine
Corpus Striatum
030227 psychiatry
Psychiatry and Mental health
medicine.anatomical_structure
Endocrinology
nervous system
chemistry
Female
business
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 00223956
- Volume :
- 81
- Database :
- OpenAIRE
- Journal :
- Journal of Psychiatric Research
- Accession number :
- edsair.doi.dedup.....4709717394a1ae65abfb4ba0cbb5fd1c