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Mechanism of the Uricosuric Activity of Ticrynafen
- Source :
- Nephron. 23:33-37
- Publication Year :
- 1979
- Publisher :
- S. Karger AG, 1979.
-
Abstract
- Studies employing pyrazinamide, which have included the measurements of clearances of pyrazinamide and pyrazinoate, as well as of ticrynafen itself and its principal metabolite, have lent support to the hypothesis that ticrynafen inhibits the tubular reabsorption of both filtered and secreted urate by nephrons of the human kidney. The inhibition of the reabsorption of secreted urate by ticrynafen appears to be quantitatively important for eliciting its uricosuric and hypouricemic responses. Because the uricosuric and natriuretic responses correlate with urinary ticrynafen concentrations, the drug appears to inhibit tubular reabsorption after gaining access to tubule fluid. As a consequence of its extensive binding to plasma proteins, clearance data suggest that tubular secretion of ticrynafen is necessary for its action.
- Subjects :
- Uricosuric
urogenital system
business.industry
Reabsorption
Metabolite
Urinary system
Natriuresis
General Medicine
Uricosuric Agents
Pharmacology
Phenoxyacetates
Pyrazinamide
Blood proteins
Glycolates
chemistry.chemical_compound
Kidney Tubules
chemistry
Nephrology
Renal physiology
Ticrynafen
Humans
Uric acid
Medicine
Diuretics
business
Subjects
Details
- ISSN :
- 14230186 and 00282766
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Nephron
- Accession number :
- edsair.doi.dedup.....470c5e5a688c5c423514bd79727c2e01