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Strawberry (Fragaria ananassa duch.) Alba extract attenuates DNA damage in lymphocytes of patients with Alzheimer’s disease
- Source :
- Journal of Food Biochemistry
- Publication Year :
- 2021
-
Abstract
- Increased levels of oxidative stress and oxidative DNA damage are common features in the pathology of Alzheimer’s disease (AD) found in neurons and peripheral cells like peripheral blood lymphocytes (PBL). Natural products such as strawberry cultivar Alba are an important source of bioactive nutrients that could help in lowering both the oxidative stress and DNA damage levels. The objective was to estimate the effects of Alba extract on DNA damage in peripheral blood lymphocytes of sporadic AD (aged 60–84 years) patients, and healthy elderly (aged 69–83 years) and young (aged 21–30 years) individuals in in vitro conditions. Comet assay was used as a sensitive technique for the evaluation of PBL DNA damage levels. Reduction of basal DNA damage level in PBL was shown in the young group after the incubation with Alba extract ranging from 25 to 200 μg/ml, with 100 μg/ml being the most effective concentration. Selected Alba extract of 100 μg/ml was further used for PBL treatment of AD and healthy elderly age matched group, displaying potential to significantly attenuate DNA damage levels in both groups (p
- Subjects :
- 030309 nutrition & dietetics
DNA damage
Biophysics
Endogeny
Pharmacology
Biology
medicine.disease_cause
Fragaria
03 medical and health sciences
0404 agricultural biotechnology
neurodegenerative disease
Alzheimer Disease
In vivo
comet assay
medicine
Humans
Lymphocytes
Aged
2. Zero hunger
0303 health sciences
Plant Extracts
04 agricultural and veterinary sciences
Cell Biology
040401 food science
In vitro
Comet assay
Ageing
ageing
Oxidative stress
DNA Damage
Food Science
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Journal of Food Biochemistry
- Accession number :
- edsair.doi.dedup.....470d6885d97afe1b9ca75a43150a5a2d