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Dosimetric comparison and biological evaluation of PET- and CT-based target delineation for LA-NSCLC using auto-planning
- Source :
- Physica Medica. 67:77-84
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Using auto-planning, the dosimetric and biological differences between PET- and CT-based target delineation in LA-NSCLC were studied. Twenty-three patients with IIIA-IIIB NSCLC were included in this retrospective study. For each patient, two AP plans (Plan_PET, Plan_CT) were generated based on PET- and CT-based gross tumor volume (GTVPET, GTVCT). The volume, boundary and center of mass (COM) of GTVPET and GTVCT were compared. Dosimetric indicators such as mean lung dose (MLD) and so on were evaluated. Tumor control probability (TCP) of GTVPET and GTVCT and normal tissue complication probability (NTCP) of total lung and heart were calculated. A paired-samples t-test was used to check for significant differences (p
- Subjects :
- Adult
Male
Organs at Risk
Lung Neoplasms
Biophysics
Normal tissue
General Physics and Astronomy
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Carcinoma, Non-Small-Cell Lung
Humans
Medicine
Radiology, Nuclear Medicine and imaging
Radiometry
Aged
Biological evaluation
Aged, 80 and over
Mean lung dose
business.industry
Radiotherapy Planning, Computer-Assisted
Radiotherapy Dosage
General Medicine
Middle Aged
Tumor control
respiratory tract diseases
Gross tumor volume
Positron-Emission Tomography
030220 oncology & carcinogenesis
Tomography, X-Ray Computed
business
Nuclear medicine
Subjects
Details
- ISSN :
- 11201797
- Volume :
- 67
- Database :
- OpenAIRE
- Journal :
- Physica Medica
- Accession number :
- edsair.doi.dedup.....472e156f74029b2ce2e5b333873136d7