Back to Search
Start Over
Acute Megakaryoblastic Leukemia Developing as Donor Cell Leukemia after Umbilical Cord Blood Transplantation
- Source :
- Internal Medicine
- Publication Year :
- 2018
- Publisher :
- Japanese Society of Internal Medicine, 2018.
-
Abstract
- A 64-year-old man with acute myeloid leukemia underwent umbilical cord blood transplantation (UCBT). After 11 months of complete remission (CR) following UCBT, the bone marrow showed 7.5% myeloblasts. CR was obtained after a single course of azacitidine monotherapy, but the myeloblasts gradually increased in the blood. We made a diagnosis of acute megakaryoblastic leukemia derived from donor cell with a fluorescence in situ hybridization (FISH) analysis of the sex chromosomes and an immunophenotypic analysis. Azacitidine was administered again and produced a therapeutic effect of stable disease. This case suggests that azacitidine may be a useful therapy for patients with acute megakaryoblastic leukemia in situations in which intensive chemotherapy and transplantation are not indicated.
- Subjects :
- Male
azacitidine
medicine.medical_specialty
donor cell leukemia
Azacitidine
Case Report
Gastroenterology
03 medical and health sciences
Acute megakaryoblastic leukemia
0302 clinical medicine
Leukemia, Megakaryoblastic, Acute
Internal medicine
Internal Medicine
Humans
Medicine
medicine.diagnostic_test
business.industry
Umbilical Cord Blood Transplantation
umbilical cord blood transplantation
Therapeutic effect
Myeloid leukemia
General Medicine
acute megakaryoblastic leukemia
Middle Aged
medicine.disease
Transplantation
Leukemia, Myeloid, Acute
medicine.anatomical_structure
030220 oncology & carcinogenesis
Cord Blood Stem Cell Transplantation
Bone marrow
business
030215 immunology
medicine.drug
Fluorescence in situ hybridization
Subjects
Details
- ISSN :
- 13497235 and 09182918
- Volume :
- 57
- Database :
- OpenAIRE
- Journal :
- Internal Medicine
- Accession number :
- edsair.doi.dedup.....4748a55149a50c9b5d296b903a4dbb2c