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Natural History of Patients Diagnosed with Cardiac Sarcoidosis at Left Ventricular Assist Device Implantation or Cardiac Transplantation
- Source :
- ASAIO journal (American Society for Artificial Internal Organs : 1992). 67(5)
- Publication Year :
- 2021
-
Abstract
- To our knowledge, natural history has not been reported for cardiac sarcoidosis (CS) diagnosed by pathologic evaluation of the apical core at left ventricular assist device (LVAD) implantation or cardiac transplantation. We retrospectively identified 232 consecutive patients meeting CS criteria. Of these patients, 54 were diagnosed by pathologic confirmation of CS, 10 after evaluation of the apical core (LVAD implant) or explanted heart (transplant). We compared clinical characteristics at initial evaluation and outcomes for these 10 patients with those of 10 patients with known CS before LVAD implant/transplant. In the study group, five patients (50%) had confirmed extracardiac sarcoidosis before LVAD implant/transplant; five had not been diagnosed with sarcoidosis. Mean (standard deviation) left ventricular ejection fraction at initial evaluation was 23% (16%), and left ventricular end-diastolic dimension was 61 (10) mm. Four patients died during follow-up; however, no survival difference was found for the 10 patients diagnosed incidentally and the group with a previous diagnosis or institutional LVAD/transplant cohorts. Patients diagnosed with CS on pathological examination of the apical core/explanted heart may have severe dilated cardiomyopathy as the initial presentation. Outcomes for patients with CS after advanced heart failure therapies may be comparable with those of non-CS patients.
- Subjects :
- Adult
Male
medicine.medical_specialty
Sarcoidosis
medicine.medical_treatment
Biomedical Engineering
Biophysics
Bioengineering
030204 cardiovascular system & hematology
Ventricular Function, Left
Biomaterials
03 medical and health sciences
0302 clinical medicine
medicine
Humans
Aged
Retrospective Studies
Heart transplantation
Heart Failure
Ejection fraction
business.industry
Dilated cardiomyopathy
General Medicine
Middle Aged
medicine.disease
Surgery
Transplantation
030228 respiratory system
Heart failure
Ventricular assist device
Heart Transplantation
Female
Implant
Heart-Assist Devices
business
Cardiomyopathies
Subjects
Details
- ISSN :
- 1538943X
- Volume :
- 67
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- ASAIO journal (American Society for Artificial Internal Organs : 1992)
- Accession number :
- edsair.doi.dedup.....47600f7880dfa1590f00698056f74899