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Screening of dicyanoisophorone-based probes for highly sensitive detection of viscosity changes in living cells and zebrafish
- Source :
- Chemical Communications. 57:9554-9557
- Publication Year :
- 2021
- Publisher :
- Royal Society of Chemistry (RSC), 2021.
-
Abstract
- Herein, seven viscosity-sensitive probes were developed via simple structural modification of dicyanoisophorone (DCO)-derived dyes. Among them, DCO-5 significantly enhances (180-fold) the response signal in highly viscous aqueous media while showing insensitivity to polarity changes or pH variations, and enables the successful detection of viscosity changes in nystatin-treated HepG2 cells, PC 12 cells and zebrafish.
- Subjects :
- Drug Evaluation, Preclinical
PC12 Cells
Catalysis
Viscosity
Materials Chemistry
Animals
Humans
Zebrafish
Fluorescent Dyes
Molecular Structure
Aqueous medium
biology
Chemistry
Metals and Alloys
Hep G2 Cells
General Chemistry
Hydrogen-Ion Concentration
biology.organism_classification
Rats
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Highly sensitive
Hepg2 cells
Ceramics and Composites
Biophysics
sense organs
Isocyanates
Subjects
Details
- ISSN :
- 1364548X and 13597345
- Volume :
- 57
- Database :
- OpenAIRE
- Journal :
- Chemical Communications
- Accession number :
- edsair.doi.dedup.....476afea7e3e2a7685468952ffa8cf318