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Assessment of the Utility of Kidney Histology as a Basis for Discarding Organs in the United States: A Comparison of International Transplant Practices and Outcomes
- Source :
- J Am Soc Nephrol
- Publication Year :
- 2020
- Publisher :
- American Society of Nephrology, 2020.
-
Abstract
- Background Many kidneys donated for transplant in the United States are discarded because of abnormal histology. Whether histology adds incremental value beyond usual donor attributes in assessing allograft quality is unknown. Methods This population-based study included patients who received a deceased donor kidney that had been biopsied before implantation according to a prespecified protocol in France and Belgium, where preimplantation biopsy findings are generally not used for decision making in the allocation process. We also studied kidneys that had been acquired from deceased United States donors for transplantation that were biopsied during allocation and discarded because of low organ quality. Using donor and recipient characteristics, we fit multivariable Cox models for death-censored graft failure and examined whether predictive accuracy (C index) improved after adding donor histology. We matched the discarded United States kidneys to similar kidneys transplanted in Europe and calculated predicted allograft survival. Results In the development cohort of 1629 kidney recipients at two French centers, adding donor histology to the model did not significantly improve prediction of long-term allograft failure. Analyses using an external validation cohort from two Belgian centers confirmed the lack of improved accuracy from adding histology. About 45% of 1103 United States kidneys discarded because of histologic findings could be accurately matched to very similar kidneys that had been transplanted in France; these discarded kidneys would be expected to have allograft survival of 93.1% at 1 year, 80.7% at 5 years, and 68.9% at 10 years. Conclusions In this multicenter study, donor kidney histology assessment during allocation did not provide substantial incremental value in ascertaining organ quality. Many kidneys discarded on the basis of biopsy findings would likely benefit United States patients who are wait listed.
- Subjects :
- education.field_of_study
medicine.medical_specialty
Kidney
Proportional hazards model
business.industry
Population
030232 urology & nephrology
Histology
General Medicine
030230 surgery
medicine.disease
Surgery
Transplantation
03 medical and health sciences
0302 clinical medicine
Kidney histology
medicine.anatomical_structure
Nephrology
Cohort
medicine
Clinical Epidemiology
education
business
Kidney transplantation
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- J Am Soc Nephrol
- Accession number :
- edsair.doi.dedup.....477c0e60d8faf3f6a85ecce75b1b337b