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Multiple Myeloma with Central Nervous System Relapse Early after Autologous Stem Cell Transplantation: A Case Report and Literature Review
- Source :
- Internal Medicine
- Publication Year :
- 2021
-
Abstract
- Few reports have so far described central nervous system (CNS) involvement in multiple myeloma (MM), which shows a poor prognosis owing to its resistance to several treatments. We herein describe a 45-year-old woman who had MM (diagnosed with IgA-κ type) with CNS relapse early after undergoing autologous hematopoietic stem cell transplantation. Because no standard treatment for CNS lesions of MM has been established, we conducted a literature review on the cerebrospinal fluid (CSF) transferability of drugs for MM, since it was considered to be a useful tool for CNS involvement. Immunomodulatory-drugs including pomalidomide exhibit a good CSF transfer ability, and, therefore, may be beneficial against the CNS involvement of MM.
- Subjects :
- Oncology
Central Nervous System
Poor prognosis
medicine.medical_specialty
medicine.medical_treatment
Central nervous system
Case Report
Hematopoietic stem cell transplantation
030204 cardiovascular system & hematology
Transplantation, Autologous
Central Nervous System Neoplasms
03 medical and health sciences
0302 clinical medicine
Cerebrospinal fluid
Autologous stem-cell transplantation
Internal medicine
Internal Medicine
medicine
Humans
pomalidmide
Multiple myeloma
business.industry
Standard treatment
Hematopoietic Stem Cell Transplantation
General Medicine
Middle Aged
Pomalidomide
medicine.disease
multiple myeloma
intrathecal chemotherapy
medicine.anatomical_structure
central nerves system
030211 gastroenterology & hepatology
Female
Neoplasm Recurrence, Local
business
craniospinal radiation
medicine.drug
Stem Cell Transplantation
Subjects
Details
- ISSN :
- 13497235
- Volume :
- 60
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Internal medicine (Tokyo, Japan)
- Accession number :
- edsair.doi.dedup.....47ab40e177980590c910a43f004e3c02