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NGAL promotes recruitment of tumor infiltrating leukocytes

Authors :
Alessio Lepore
Antonio Leonardi
Michele Cillo
Francesco Pacifico
Stefano Mellone
Luna Pisa
Pacifico, Francesco
Pisa, Luna
Mellone, Stefano
Cillo, Michele
Lepore, Alessio
Leonardi, Antonio
Source :
Oncotarget 9 (2018): 30761–30772. doi:10.18632/oncotarget.25625, info:cnr-pdr/source/autori:Pacifico, Francesco; Pisa, Luna; Mellone, Stefano; Cillo, Michele; Lepore, Alessio; Leonardi, Antonio/titolo:NGAL promotes recruitment of tumor infiltrating leukocytes/doi:10.18632%2Foncotarget.25625/rivista:Oncotarget/anno:2018/pagina_da:30761/pagina_a:30772/intervallo_pagine:30761–30772/volume:9, Oncotarget
Publication Year :
2018
Publisher :
Impact Journals, Albany, N.Y. , Stati Uniti d'America, 2018.

Abstract

We have previously shown that Neutrophil Gelatinase-Associated Lipocalin (NGAL) is strongly expressed in thyroid carcinomas, especially of anaplastic type, where it protects neoplastic cells from serum deprivation-induced apoptosis and enhances tumor invasivity by regulating MMP-9 activity. Here we demonstrate that NGAL-containing conditioned medium from human anaplastic thyroid carcinoma (ATC) cells is able to induce monocyte migration via up-regulation of a number of different chemokines. The enhanced chemokines transcription is due to the NGAL-mediated intracellular iron uptake. Very importantly, mice tumor allografts raised from subcutaneous injection of syngeneic colon carcinoma cell lines, expressing high levels of NGAL, show a dense leukocyte infiltrate which strongly decreases in tumor allografts from NGAL-depleted cell injected mice. Our results indicate that the NGAL promotes leukocytes recruitment in tumor microenvironment through iron-mediated chemokines production.

Details

Language :
English
Database :
OpenAIRE
Journal :
Oncotarget 9 (2018): 30761–30772. doi:10.18632/oncotarget.25625, info:cnr-pdr/source/autori:Pacifico, Francesco; Pisa, Luna; Mellone, Stefano; Cillo, Michele; Lepore, Alessio; Leonardi, Antonio/titolo:NGAL promotes recruitment of tumor infiltrating leukocytes/doi:10.18632%2Foncotarget.25625/rivista:Oncotarget/anno:2018/pagina_da:30761/pagina_a:30772/intervallo_pagine:30761–30772/volume:9, Oncotarget
Accession number :
edsair.doi.dedup.....47b342411e0428d29da82b97d5fa6198
Full Text :
https://doi.org/10.18632/oncotarget.25625