Back to Search
Start Over
Ultrastructural studies of the bile duct in alcoholic liver disease
- Source :
- The Kurume medical journal. 39(4)
- Publication Year :
- 1992
-
Abstract
- The fine structural characteristics of the bile duct in patients with alcoholic disease are described. Dark cell metamorphosis, edematous microvilli, and increased number of pinocytotic vesicles on the basal wall surface of the duct epithelium were observed. These alterations may be interpreted as evidence of disordered water metabolism, probably reflecting secretion and reabsorption hyperfunction in the duct epithelium. In addition, widened intercellular spaces in the basal half of the epithelium suggested retention of fluid following reverse pinocytosis along the lateral cell surface. Although no alterations of the duct epithelium distinct from those in patients with other liver diseases were apparent in patients with alcoholic liver disease, the basement membrane of the bile duct exhibited unusual duplication with multiple layers and occasional loop-formation in lacunae on the basal surface.
- Subjects :
- Adult
Male
Alcoholic liver disease
medicine.medical_specialty
Biology
Cholangiocyte
Basement Membrane
Basal (phylogenetics)
Internal medicine
medicine
Humans
Liver Diseases, Alcoholic
Basement membrane
Organelles
Bile duct
Pinocytosis
Cell Membrane
General Medicine
Middle Aged
medicine.disease
Epithelium
Microscopy, Electron
medicine.anatomical_structure
Endocrinology
Dark cell
Female
Bile Ducts
Subjects
Details
- ISSN :
- 00235679
- Volume :
- 39
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- The Kurume medical journal
- Accession number :
- edsair.doi.dedup.....47bc14686a42b71b1c64966c8a0b21bb