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Hematologic Aspects of Systemic Lupus Erythematosus

Authors :
Daniel R. Budman
Alfred D. Steinberg
Source :
Annals of Internal Medicine. 86:220
Publication Year :
1977
Publisher :
American College of Physicians, 1977.

Abstract

Anemia occurs in more than one half of patients with systemic lupus erythematosus and is usually attributed to "chronic disease." Approximately 10% of patients with a positive Coombs' test manifest clinically significant hemolysis. Leukopenia affects both granulocytic and lymphocytic lines and may be caused by autoantibodies. Nevertheless, enhancement of B lymphocyte function occurs in active disease, perhaps due to a loss of regulatory T cells. Most patients have increased production and increased peripheral destruction of thrombocytes, with a normal circulation platelet count. Thrombocytopenia is usually caused by increased destruction. Qualitative abnormalities of platelet aggregation also occur. Circulation anticoagulants are not rare; however, spontaneous bleeding is uncommon. The anticoagulants, immunoglobulins directed against clotting factors, assume importance for invasive procedures. Most clinically significant hematopoietic abnormalities can be suppressed by corticosteroids; however, splenectomy, or immunosuppressive agents, or both, may be indicated for patients who respond inadequately to corticosteroids.

Details

ISSN :
00034819
Volume :
86
Database :
OpenAIRE
Journal :
Annals of Internal Medicine
Accession number :
edsair.doi.dedup.....47bc5f9bf2bb3c707a213d18274e01b0
Full Text :
https://doi.org/10.7326/0003-4819-86-2-220