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Prolonged complete hematologic response in relapsed/refractory T-large granular lymphocyte leukemia after bendamustine treatment
- Source :
- Europe PubMed Central, Translational Medicine @ UniSa
- Publication Year :
- 2016
- Publisher :
- Universita' degli Studi di Salerno, 2016.
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Abstract
- T-large granular lymphocyte leukemia (T-LGLL) is a chronic clonal proliferation of effector memory cytotoxic CD3+CD57+CD56− T cells and the current guidelines suggest immunosuppressive therapy as first-line therapy, but the treatment of refractory/relapsed patients is still challenging due to the lack of prospective studies. We describe a series of two refractory/relapsed T-LGLL patients successfully treated with bendamustine, a chemotherapeutic agent largely used for B-cell neoplasms, but poorly investigated for the treatment of T-cell diseases. Complete remission (CR) was achieved in 3 and 6 months, respectively, and maintained for at least 20 months. One patient relapsed after a 20-month CR, but she was responsive to bendamustine therapy again, obtaining a further prolonged CR. Bendamustine as single agent or in combination could be a feasible therapeutic option in refractory/relapsed T-LGLL, especially for elderly patients because of its safety profile.
Details
- Database :
- OpenAIRE
- Journal :
- Europe PubMed Central, Translational Medicine @ UniSa
- Accession number :
- edsair.doi.dedup.....47e008f5a4f08cec77e9e581ac887e73
- Full Text :
- https://doi.org/10.14273/unisa-2671