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Supplemental Material from Toward Personalized Lymphoma Immunotherapy: Identification of Common Driver Mutations Recognized by Patient CD8+ T Cells

Authors :
Brad H. Nelson
Nicol Macpherson
Ryan D. Morin
Marco A. Marra
Brian R. Berry
Randy D. Gascoyne
Joseph M. Connors
Steven P. Treon
David R. Kroeger
Lewis Liu
Stephen Yu
Zabrina L. Brumme
Zusheng Zong
Aniqa Shahid
Colin G. Sedgwick
Julie S. Nielsen
Publication Year :
2023
Publisher :
American Association for Cancer Research (AACR), 2023.

Abstract

Supplemental Methods. Table S1. Frequency of hematopoietic subsets in PBMC at all time points for patient samples used for in vitro immunogenicity experiments Table S2: Clinical characteristics of follicular lymphoma cohorts Table S3. Amino acid changes encoded by somatic mutations identified in candidate genes in follicular lymphoma cohort Table S4. Patient HLA class I alleles for in vitro immunogenicity cohort Figure S1. The number of mutant peptides predicted to bind patient-specific HLA class I molecules in the sequencing cohort. Figure S2. Clinical timeline for 13-patient cohort selected for in vitro immunogenicity studies. Figure S3. CD8 status of mutant peptide-reactive T cells.

Details

Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....47f1705ad7aee90728ec207042a33d0c
Full Text :
https://doi.org/10.1158/1078-0432.22456929