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Enantioselective Synthesis of Chiral α-Aryl or α-Alkyl Substituted Ethylphosphonates via Rh-Catalyzed Asymmetric Hydrogenation with a P-Stereogenic BoPhoz-Type Ligand
- Source :
- The Journal of Organic Chemistry. 74:4408-4410
- Publication Year :
- 2009
- Publisher :
- American Chemical Society (ACS), 2009.
-
Abstract
- An enantioselective synthesis of optically active 1-aryl or 1-alkyl substituted ethylphosphonates, based on the first Rh-catalyzed asymmetric hydrogenation of corresponding alpha,beta-unsaturated precursors with a P-stereogenic BoPhoz-type ligand under the mild condition, was developed, in which a wide range of 1-aryl or 1-alkyl substituted ethylphosphonates were achieved in up to 98% ee.
- Subjects :
- chemistry.chemical_classification
Ligand
Stereochemistry
Aryl
Organic Chemistry
Asymmetric hydrogenation
Organophosphonates
Enantioselective synthesis
Stereoisomerism
Ligands
Chemical synthesis
Catalysis
Stereocenter
chemistry.chemical_compound
Organophosphorus Compounds
chemistry
Rhodium
Hydrogenation
Enantiomeric excess
Alkyl
Subjects
Details
- ISSN :
- 15206904 and 00223263
- Volume :
- 74
- Database :
- OpenAIRE
- Journal :
- The Journal of Organic Chemistry
- Accession number :
- edsair.doi.dedup.....480b5cd570d8830c71be3d183e7e2b86