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2-Cyano-4-fluoro-1-thiovalylpyrrolidine analogues as potent inhibitors of DPP-IV
- Source :
- Bioorganicmedicinal chemistry letters. 15(23)
- Publication Year :
- 2005
-
Abstract
- We report the synthesis and biological activity of a series of 2-cyano-4-fluoro-1-thiovalylpyrrolidine inhibitors of DPP-IV. Within this series, compound 19 provided a potent, selective, and orally active DPP-IV inhibitor which demonstrated a very long duration of action in both rat and dog.
- Subjects :
- animal structures
Pyrrolidines
Nitrile
Stereochemistry
Dipeptidyl Peptidase 4
Clinical Biochemistry
Pharmaceutical Science
Administration, Oral
Biochemistry
Chemical synthesis
Sulfone
chemistry.chemical_compound
Dogs
Oral administration
Drug Discovery
Animals
heterocyclic compounds
Protease Inhibitors
Molecular Biology
Dipeptidyl peptidase-4
chemistry.chemical_classification
biology
Organic Chemistry
Biological activity
Valine
Rats
Enzyme
chemistry
Enzyme inhibitor
biology.protein
Molecular Medicine
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 15
- Issue :
- 23
- Database :
- OpenAIRE
- Journal :
- Bioorganicmedicinal chemistry letters
- Accession number :
- edsair.doi.dedup.....4811373062218e9c37554b0a1ca38256