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Association Between the PTPN2 Gene and Crohnʼs Disease
Association Between the PTPN2 Gene and Crohnʼs Disease
- Source :
- Inflammatory Bowel Diseases. 19:1149-1155
- Publication Year :
- 2013
- Publisher :
- Oxford University Press (OUP), 2013.
-
Abstract
- Background: Although genome-wide association studies (GWAS) and subsequent meta-analyses have confirmed associations between the PTPN2 (protein tyrosine phosphatase, nonreceptor type 2) gene and Crohn's disease (CD), the potential causal variants remain unidentified. We aimed to dissect potential causal CD-associated PTPN2 variants, assess their functional significance, and relate PTPN2 protein expression with inflammation in CD. Methods: A 3-stage study was carried out. In stage 1, we genotyped tagging single nucleotide polymorphisms (tag-SNPs) in the PTPN2 gene in a sample of patients with CD (
- Subjects :
- Male
Linkage disequilibrium
Adolescent
Genotype
In silico
Immunoblotting
Single-nucleotide polymorphism
Genome-wide association study
Biology
Polymerase Chain Reaction
Polymorphism, Single Nucleotide
Linkage Disequilibrium
Exon
Crohn Disease
Risk Factors
Humans
Immunology and Allergy
SNP
Genetic Predisposition to Disease
Intestinal Mucosa
Child
Promoter Regions, Genetic
Gene
Genetic association
Inflammation
Genetics
Protein Tyrosine Phosphatase, Non-Receptor Type 2
Infant, Newborn
Gastroenterology
Computational Biology
Infant
Prognosis
Case-Control Studies
Child, Preschool
Female
Biomarkers
Follow-Up Studies
Subjects
Details
- ISSN :
- 10780998
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Inflammatory Bowel Diseases
- Accession number :
- edsair.doi.dedup.....4819dd425f0be0c320b4f8d1a28bc871
- Full Text :
- https://doi.org/10.1097/mib.0b013e318280b181