Back to Search Start Over

Association Between the PTPN2 Gene and Crohnʼs Disease

Association Between the PTPN2 Gene and Crohnʼs Disease

Authors :
David M. Israel
Christopher S. Carlson
Christophe Faure
Jinsong Dong
Patrick Beaulieu
David R. Mack
Philippe Lambrette
Devendra Amre
Alfreda Krupoves
Emile Levy
Guy Grimard
Vijay Kumar
Irina Costea
Ernest G. Seidman
Valérie Marcil
Source :
Inflammatory Bowel Diseases. 19:1149-1155
Publication Year :
2013
Publisher :
Oxford University Press (OUP), 2013.

Abstract

Background: Although genome-wide association studies (GWAS) and subsequent meta-analyses have confirmed associations between the PTPN2 (protein tyrosine phosphatase, nonreceptor type 2) gene and Crohn's disease (CD), the potential causal variants remain unidentified. We aimed to dissect potential causal CD-associated PTPN2 variants, assess their functional significance, and relate PTPN2 protein expression with inflammation in CD. Methods: A 3-stage study was carried out. In stage 1, we genotyped tagging single nucleotide polymorphisms (tag-SNPs) in the PTPN2 gene in a sample of patients with CD (

Details

ISSN :
10780998
Volume :
19
Database :
OpenAIRE
Journal :
Inflammatory Bowel Diseases
Accession number :
edsair.doi.dedup.....4819dd425f0be0c320b4f8d1a28bc871
Full Text :
https://doi.org/10.1097/mib.0b013e318280b181