Back to Search
Start Over
Dilatation of the Ductus Arteriosus by Prostaglandins and Prostaglandin's Precursors
- Source :
- Pediatric Research. 14:1074-1077
- Publication Year :
- 1980
- Publisher :
- Springer Science and Business Media LLC, 1980.
-
Abstract
- We studied the effects of prostaglandins and their precursors in animal models. Rabbit ductus arteriosus constricted rapidly after delivery. PGE1, and PGE2, and arachidonic acid injected SC dilated the ductus over 60 min. Orogastrically administered PGE2 dilated the ductus for 3 hr. PGF2a and arachidonic acid showed weak ductus-dilating effects. Response of the ductus to PGE1 was most prominent in the first hr after birth. Pretreatment with indomethacin blocked the ductus-dilating effect of arachidonic acid.
- Subjects :
- congenital, hereditary, and neonatal diseases and abnormalities
medicine.medical_specialty
Time Factors
Prostaglandin
Vasodilation
Arachidonic Acids
chemistry.chemical_compound
Pregnancy
Ductus arteriosus
Internal medicine
medicine
Animals
Humans
cardiovascular diseases
business.industry
Age Factors
Infant, Newborn
Ductus Arteriosus
medicine.anatomical_structure
Endocrinology
Animals, Newborn
chemistry
embryonic structures
Pediatrics, Perinatology and Child Health
Prostaglandins
cardiovascular system
Cardiology
Female
lipids (amino acids, peptides, and proteins)
Arachidonic acid
Rabbits
business
Infant, Premature
Subjects
Details
- ISSN :
- 15300447 and 00313998
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Pediatric Research
- Accession number :
- edsair.doi.dedup.....481c1a9d7a674ab36e3ee56f831efcf4