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Abnormal cortical sources of resting state electroencephalographic rhythms in single treatment-naïve HIV individuals: A statistical z-score index
- Source :
- Clinical Neurophysiology. 127:1803-1812
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- This study tested a simple statistical procedure to recognize single treatment-naïve HIV individuals having abnormal cortical sources of resting state delta (4 Hz) and alpha (8-13 Hz) electroencephalographic (EEG) rhythms with reference to a control group of sex-, age-, and education-matched healthy individuals. Compared to the HIV individuals with a statistically normal EEG marker, those with abnormal values were expected to show worse cognitive status.Resting state eyes-closed EEG data were recorded in 82 treatment-naïve HIV (39.8 ys.±1.2 standard error mean, SE) and 59 age-matched cognitively healthy subjects (39 ys.±2.2 SE). Low-resolution brain electromagnetic tomography (LORETA) estimated delta and alpha sources in frontal, central, temporal, parietal, and occipital cortical regions.Ratio of the activity of parietal delta and high-frequency alpha sources (EEG marker) showed the maximum difference between the healthy and the treatment-naïve HIV group. Z-score of the EEG marker was statistically abnormal in 47.6% of treatment-naïve HIV individuals with reference to the healthy group (p0.05). Compared to the HIV individuals with a statistically normal EEG marker, those with abnormal values exhibited lower mini mental state evaluation (MMSE) score, higher CD4 count, and lower viral load (p0.05).This statistical procedure permitted for the first time to identify single treatment-naïve HIV individuals having abnormal EEG activity.This procedure might enrich the detection and monitoring of effects of HIV on brain function in single treatment-naïve HIV individuals.
- Subjects :
- Male
medicine
HIV Infections
Pilot Projects
Audiology
Electroencephalography
delta/alpha power density
0302 clinical medicine
EEG
Cerebral Cortex
Delta/alpha power density
Human immunodeficiency virus (HIV)
Low-resolution brain electromagnetic source tomography (LORETA)
Resting-state electroencephalography (EEG)
Z-score
Adult
Humans
Viral Load
Rest
human immunodeficiency virus
medicine.diagnostic_test
05 social sciences
low-resolution brain electromagnetic source tomography
LORETA
Sensory Systems
medicine.anatomical_structure
Neurology
Cerebral cortex
Psychology
Viral load
medicine.medical_specialty
Settore MED/17 - Malattie Infettive
resting-state electroencephalography
Alpha (ethology)
Standard score
050105 experimental psychology
03 medical and health sciences
Rhythm
Physiology (medical)
0501 psychology and cognitive sciences
Resting state fMRI
HIV
adult
cerebral cortex
electroencephalography
HIV infections
humans
male
pilot projects
viral load
rest
sensory systems
neurology
physiology
Standard error
Neurology (clinical)
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 13882457
- Volume :
- 127
- Database :
- OpenAIRE
- Journal :
- Clinical Neurophysiology
- Accession number :
- edsair.doi.dedup.....4826a00d61793a87651ba7335960a4ee