Endoglin in circulation predicts favourable prognosis for pemetrexed treatment in advanced non-small cell lung cancer

Supplementary Fig. 1. Effects of cathepsin S, matrix metalloproteinase 3 and 9 (MMP3 and MMP9) levels on pemetrexed responsiveness in the cohort. (A) Cathepsin S, (B) MMP3 and (C) MMP9 concentration (ng/mL) in pemetrexed responders and nonresponders measured using ELISA. Progression-free survival of groups with high and low (D) Cathepsin S, (E) MMP3 and (F) MMP9 analysed using the Kaplan–Meier method and the log rank test.