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Interpretation of karyotype evolution should consider chromosome structural constraints
- Source :
- Trends in Genetics. 27:207-216
- Publication Year :
- 2011
- Publisher :
- Elsevier BV, 2011.
-
Abstract
- Comparative genetics, genomics and cytogenetics provide tools to trace the evolutionary history of extant genomes. Yet, the interpretation of rapidly increasing genomic data is not always done in agreement with constraints determined by chromosome structural features and by insights obtained from chromosome mutagenesis. The terms 'non-reciprocal chromosome translocation', 'chromosome fusion' and 'centromere shift' used to explain genomic differences among organisms are misleading and often do not correctly reflect the mechanisms of chromosome rearrangements underlying the evolutionary karyotypic variation. Here, we (re)interpret evolutionary genome alterations in a parsimonious way and demonstrate that results of comparative genomics and comparative chromosome painting can be explained on the basis of known primary and secondary chromosome rearrangements. Therefore, some widespread terms used in comparative and evolutionary genomics should be either avoided (e.g. non-reciprocal translocation) or redefined (e.g. chromosome fusion and centromere shift).
- Subjects :
- 0106 biological sciences
medicine.medical_specialty
Chromosomal translocation
Genomics
Biology
01 natural sciences
Genome
Chromosomes
Chromosome Painting
Evolution, Molecular
03 medical and health sciences
Chromosome (genetic algorithm)
Centromere
Genetics
medicine
Animals
Humans
030304 developmental biology
Comparative genomics
0303 health sciences
Cytogenetics
Karyotype
Evolutionary biology
Karyotyping
010606 plant biology & botany
Subjects
Details
- ISSN :
- 01689525
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Trends in Genetics
- Accession number :
- edsair.doi.dedup.....483faf4b3a378359154be6e06e2074cb