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Cytomegalovirus aggravates the autoimmune phenomenon in systemic autoimmune diseases
- Source :
- Microbial Pathogenesis. 120:132-139
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Background Human Cytomegalovirus (CMV), because of its ability to extensively manipulate host immunity during active infection, has been suggested to be involved in autoimmunity. However, its influence on T-cells and cytokines in systemic autoimmune diseases like systemic lupus erythematosus (SLE) and systemic sclerosis (SSc) is indistinct. Methods We investigated the in-vitro response of T lymphocytes from SLE and SSc patients to CMV antigen. Functional activity of T lymphocytes was determined by estimating Th1 (IL-2 and IFN-γ) and Th2 (IL-4 and IL-10) cytokines. Results We observed that CMV antigen stimulation in-vitro resulted in significant increase in CD4:CD8 T-cell ratio in peripheral blood mononuclear cells (PBMCs) from SLE and SSc patients; response dominated by CD4+ than CD8+ memory T-cells. SSc T-cell response was differentiated by aberrant increase in CD4+CD25+ T-cells. CMV antigen caused elevation in IL-4 and IFN-γ production in both patient PBMCs, whereas IL-2 was also raised in SLE PBMCs. The development of large pool of memory T-cells and overproduction of IFN-γ may result in flare-up of autoimmunity in these patients. Conclusion Our study provides an insight into the immunopathological potential of CMV-reactive immune cells to develop new potential strategies for targeted therapeutic intervention.
- Subjects :
- Adult
CD4-Positive T-Lymphocytes
Male
0301 basic medicine
Human cytomegalovirus
Adolescent
T-Lymphocytes
Congenital cytomegalovirus infection
Cytomegalovirus
CD8-Positive T-Lymphocytes
medicine.disease_cause
Microbiology
Peripheral blood mononuclear cell
Autoimmune Diseases
Autoimmunity
Interferon-gamma
Young Adult
03 medical and health sciences
Th2 Cells
0302 clinical medicine
Immune system
Antigen
Humans
Lupus Erythematosus, Systemic
Medicine
IL-2 receptor
Child
skin and connective tissue diseases
Antigens, Viral
030203 arthritis & rheumatology
Scleroderma, Systemic
business.industry
Interleukin-2 Receptor alpha Subunit
Middle Aged
Th1 Cells
medicine.disease
Interleukin-10
030104 developmental biology
Infectious Diseases
Cytomegalovirus Infections
Immunology
Leukocytes, Mononuclear
Cytokines
Interleukin-2
Female
Interleukin-4
business
CD8
Subjects
Details
- ISSN :
- 08824010
- Volume :
- 120
- Database :
- OpenAIRE
- Journal :
- Microbial Pathogenesis
- Accession number :
- edsair.doi.dedup.....484c9debd9ec5f98dee381cbf86353c4