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Development and characterization of co-loaded curcumin/triazole-halloysite systems and evaluation of their potential anticancer activity
- Publication Year :
- 2014
- Publisher :
- Elsevier Science Limited, 2014.
-
Abstract
- Positively charged halloysite nanotubes functionalized with triazolium salts (f-HNT) were employed as a carrier for curcumin molecules delivery. The synthesis of these f-HNT new materials is described. Their interaction with curcumin was evaluated by means dynamic light scattering (DLS) and UV–vis spectroscopy in comparison with pristine unmodified HNT (p-HNT). The curcumin load into HNT was estimated by thermogravimetric analysis (TGA) measurements, while the morphology was investigated by scanning electron microscopy (SEM) techniques. Release of curcumin from f-HNT, at three different pH values, by means of UV–vis spectroscopy was also studied. Furthermore, different cancer cell lines were used to evaluate the potential cytotoxic effect of HNT at different concentrations and culture times. The results indicated that the f-HNT drug carrier system improves the solubility of curcumin in water, and that the drug-loaded f-HNT exerted cytotoxic effects against different cell lines.
- Subjects :
- Thermogravimetric analysis
Curcumin
Cell Survival
Scanning electron microscope
Triazole
Pharmaceutical Science
Antineoplastic Agents
engineering.material
Halloysite
Settore MED/13 - Endocrinologia
Drug Incompatibility
chemistry.chemical_compound
halloysite nanotubes, triazolium salts, drug carrier, curcumin, in vitro anticancer activity
Dynamic light scattering
Cell Line, Tumor
Humans
Technology, Pharmaceutical
Organic chemistry
Solubility
Cell Proliferation
Settore CHIM/02 - Chimica Fisica
Drug Carriers
Nanotubes
Settore CHIM/06 - Chimica Organica
Triazoles
Drug Liberation
chemistry
Thermogravimetry
Microscopy, Electron, Scanning
engineering
Clay
Aluminum Silicates
Drug carrier
Nuclear chemistry
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....48a31d27575025d2d2dec6ce951991d9