The value of MMP-9 for breast and non-small cell lung cancer patients' survival

Purpose: Matrix metalloproteinases (MMPs) are implicated in cancer cells invasion and metastasis processes and have been investigated as potential cancer biomarkers. In this study MMP-9 gene expression and MMP-9 -1562 C/T polymorphism in breast and non-small cell lung cancer patients’ blood and tumor samples and its correlation with clinicopathological parameters were investigated. Material/Methods: MMP-9 gene expression was assessed by reverse transcription – polymerase chain reaction method in 108 cancer patients’ blood and tumor samples. MMP-9 -1562 C/T polymorphism was determined by the polymerase chain reaction – based restriction fragment length polymorphism method. Results: Significant relationship of MMP-9 gene expression and tumor differentiation grade was found only between groups with G1 and G3 breast tumors. Low survival rates were identified among positive MMP-9 expression in blood and ductal carcinoma of the breast (p=0.01) and negative progesterone receptor reaction (p=0.04). Significant differences in the distribution among genotypes were found between groups with stage I and stages III/IV (p=0.005) as well as between groups with lymph node status N0 and N1 (p