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Altered neurobiological processing of unintentional social norm violations
- Source :
- Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 5(10), 981-990. ELSEVIER, Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. Elsevier Inc., BIOL PSYCHIAT-COGN N, 5(10), 981-990. ELSEVIER
- Publication Year :
- 2020
- Publisher :
- ELSEVIER, 2020.
-
Abstract
- BACKGROUND: Patients with social anxiety disorder (SAD) fear negative evaluation in social situations. Specifically, previous work indicated that social anxiety is associated with increased medial prefrontal cortex activation in response to unintentional social norm (SN) transgressions, accompanied by increased embarrassment ratings for such SN violations. Here, we used data from the multiplex, multigenerational LFLSAD (Leiden Family Lab study on Social Anxiety Disorder), which involved two generations of families genetically enriched for SAD, and investigated whether these neurobiological and behavioral correlates of unintentional SN processing are SAD endophenotypes. Of four endophenotype criteria, we examined two: first, the cosegregation of these characteristics with social anxiety (SA) within families of SAD probands (criterion 4), and second, the heritability of the candidate endophenotypes (criterion 3).METHODS: Participants (n = 110, age range 9.0-61.5 years, eight families) performed the revised Social Norm Processing Task; functional magnetic resonance imaging data and behavioral ratings related to this paradigm were used to examine whether brain activation in response to processing unintentional SN violations and ratings of embarrassment were associated with SA levels. Next, heritability of these measurements was estimated.RESULTS: As expected, voxelwise functional magnetic resonance imaging analyses revealed positive associations between SA levels and brain activation in the medial prefrontal cortex and medial temporal gyrus, superior temporal gyrus, and superior temporal sulcus, and these brain activation levels displayed moderate to moderately high heritability. Furthermore, although SA levels correlated positively with behavioral ratings of embarrassment for SN transgressions, these behavioral characteristics were not heritable.CONCLUSIONS: These results show, for the first time, that brain responses in the medial prefrontal cortex and medial temporal gyrus, superior temporal gyrus, and superior temporal sulcus, related to processing unintentional SN violations, provide a neurobiological candidate endophenotype of SAD.
- Subjects :
- Adult
medicine.medical_specialty
Adolescent
Endophenotypes
Cognitive Neuroscience
media_common.quotation_subject
Embarrassment
Audiology
Anxiety
050105 experimental psychology
03 medical and health sciences
Superior temporal gyrus
Young Adult
0302 clinical medicine
Gyrus
medicine
Social Norms
Humans
0501 psychology and cognitive sciences
Radiology, Nuclear Medicine and imaging
Prefrontal cortex
Child
Social anxiety disorder
Biological Psychiatry
media_common
medicine.diagnostic_test
05 social sciences
Social anxiety
fMRI
Superior temporal sulcus
Fear
Middle Aged
Magnetic Resonance Imaging
Family study
medicine.anatomical_structure
Endophenotype
Intentionality
Neurology (clinical)
Social norm processing
Psychology
Functional magnetic resonance imaging
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 24519022
- Database :
- OpenAIRE
- Journal :
- Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 5(10), 981-990. ELSEVIER, Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. Elsevier Inc., BIOL PSYCHIAT-COGN N, 5(10), 981-990. ELSEVIER
- Accession number :
- edsair.doi.dedup.....48c31882ebff16a3bab8447fec01f121