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Use of cardiovascular drugs and risk of incident heart failure in patients with atrial fibrillation
- Source :
- J Clin Hypertens (Greenwich)
- Publication Year :
- 2020
- Publisher :
- Wiley, 2020.
-
Abstract
- Congestive heart failure (CHF) is the most important cause of death in patients with atrial fibrillation (AF). We aimed to study the association between cardiovascular drugs in AF patients and incident CHF. The study population included all adults (n = 120 756) aged ≥45 years diagnosed with AF in Sweden diagnosed for the period 1998‐2006. Outcome was incident congestive heart failure (follow‐up 2007‐2015) in AF patients. Associations between treatment with cardiovascular pharmacotherapies and CHF were evaluated using Cox regression to estimate hazard ratios (HRs) with 95% CIs, after adjustment for age, sociodemographic variables, and comorbidities. During a mean 5.3 years (SD 3.0) of follow‐up, there were 28 257 (23.4%) incident cases of CHF. Treatment with beta‐1‐selective and non‐selective beta‐blockers and statins was associated with lower risks of incident CHF in men, HR, (95% CI); 0.90, (0.87‐0.94); 0.90, (0.84‐0.97), and 0.94, (0.90‐0.99), respectively. Only beta‐1‐selective beta‐blockers were protective in women 0.94 (0.91‐0.98). Treatment with loop diuretics, potassium‐saving agents, ACE inhibitors, and angiotensin receptor blockers was associated with a higher risk of CHF. For men, treatment with heart‐active calcium channel blockers also led to a higher risk of CHF. In conclusion, we found that beta‐blockers, in particular, but also statins were associated with lower risk of incident CHF in patients with AF.
- Subjects :
- Male
medicine.medical_specialty
Epidemiology
Endocrinology, Diabetes and Metabolism
030204 cardiovascular system & hematology
Lower risk
03 medical and health sciences
0302 clinical medicine
Internal medicine
Atrial Fibrillation
Internal Medicine
medicine
Humans
In patient
cardiovascular diseases
030212 general & internal medicine
Cause of death
Heart Failure
Sweden
Proportional hazards model
business.industry
Hazard ratio
Cardiovascular Agents
Atrial fibrillation
Middle Aged
medicine.disease
Heart failure
Hypertension
Cardiology
Population study
Female
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 17517176 and 15246175
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- The Journal of Clinical Hypertension
- Accession number :
- edsair.doi.dedup.....48c5cde51145af238b402d7fd914febe
- Full Text :
- https://doi.org/10.1111/jch.13931