Back to Search
Start Over
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study
- Source :
- PLoS Genetics, e1006166, PLoS Genetics, Public Library of Science, 2015, 11 (10), pp.e1005378. ⟨10.1371/journal.pgen.1005378⟩, PLoS Genetics, 11(10):e1005378. Public Library of Science, PLOS genetics (Online) 11 (2015): e1005378. doi:10.1371/journal.pgen.1005378, info:cnr-pdr/source/autori:Winkler, Thomas W; Justice, Anne E; Graff, Mariaelisa; Barata, Llilda; Feitosa, Mary F; Chu, Su; Czajkowski, Jacek; Esko, Tonu; Fall, Tove; Kilpelainen, Tuomas O; Lu, Yingchang; Magi, Reedik; Mihailov, Evelin; Pers, Tune H; Rueger, Sina; Teumer, Alexander; Ehret, Georg B; Ferreira, Teresa; Heard-Costa, Nancy L; Karjalainen, Juha; Lagou, Vasiliki; Mahajan, Anubha; Neinast, Michael D; Prokopenko, Inga; Simino, Jeannette; Teslovich, Tanya M; Jansen, Rick; Westra, Harm-Jan; White, Charles C; Absher, Devin; Ahluwalia, Tarunveer S; Ahmad, Shafqat; Albrecht, Eva; Alves, Alexessander Couto; Bragg-Gresham, Jennifer L; de Craen, Anton J M; Bis, Joshua C; Bonnefond, Amelie; Boucher, Gabrielle; Cadby, Gemma; Cheng, Yu-Ching; Chiang, Charleston W K; Delgado, Graciela; Demirkan, Ayse; Dueker, Nicole; Eklund, Niina; Eiriksdottir, Gudny; Eriksson, Joel; Feenstra, Bjarke; Fischer, Krista; Frau, Francesca; Galesloot, Tessel E; Geller, Frank; Goel, Anuj; Gorski, Mathias; Grammer, Tanja B; Gustafsson, Stefan; Haitjema, Saskia; Hottenga, Jouke-Jan; Huffman, Jennifer E; Jackson, Anne U; Jacobs, Kevin B; Johansson, Asa; Kaakinen, Marika; Kleber, Marcus E; Lahti, Jari; Mateo Leach, Irene; Lehne, Benjamin; Liu, Youfang; Lo, Ken Sin; Lorentzon, Mattias; Luan, Jian'an; Madden, Pamela A F; Mangino, Massimo; McKnight, Barbara; Medina-Gomez, Carolina; Monda, Keri L; Montasser, May E; Muller, Gabriele; Muller-Nurasyid, Martina; Nolte, Ilja M; Panoutsopoulou, Kalliope; Pascoe, Laura; Paternoster, Lavinia; Rayner, Nigel W; Renstrom, Frida; Rizzi, Federica; Rose, Lynda M; Ryan, Kathy A; Salo, Perttu; Sanna, Serena; Scharnagl, Hubert; Shi, Jianxin; Smith, Albert Vernon; Southam, Lorraine; Stancakova, Alena; Steinthorsdottir, Valgerdur; Strawbridge, Rona J; Sung, Yun Ju; Tachmazidou, Ioanna; Tanaka, Toshiko; Thorleifsson, Gudmar; Trompet, Stella; Pervjakova, Natalia; Tyrer, Jonathan P; Vandenput, Liesbeth; van der Laan, Sander W; van der Velde, Nathalie; van Setten, Jessica; van Vliet-Ostaptchouk, Jana V; Verweij, Niek; Vlachopoulou, Efthymia; Waite, Lindsay L; Wang, Sophie R; Wang, Zhaoming; Wild, Sarah H; Willenborg, Christina; Wilson, James F; Wong, Andrew; Yang, Jian; Yengo, Loic; Yerges-Armstrong, Laura M; Yu, Lei; Zhang, Weihua; Zhao, Jing Hua; Andersson, Ehm A; Bakker, Stephan J L; Baldassarre, Damiano; Banasik, Karina; Barcella, Matteo; Barlassina, Cristina; Bellis, Claire; Benaglio, Paola; Blangero, John; Bluher, Matthias; Bonnet, Fabrice; Bonnycastle, Lori L; Boyd, Heather A; Bruinenberg, Marcel; Buchman, Aron S; Campbell, Harry; Chen, Yii-Der Ida; Chines, Peter S; Claudi-Boehm, Simone; Cole, John; Collins, Francis S; de Geus, Eco J C; de Groot, Lisette C P G M; Dimitriou, Maria; Duan, Jubao; Enroth, Stefan; Eury, Elodie; Farmaki, Aliki-Eleni; Forouhi, Nita G; Friedrich, Nele; Gejman, Pablo V; Gigante, Bruna; Glorioso, Nicola; Go, Alan S; Gottesman, Omri; GraSSler, Jurgen; Grallert, Harald; Grarup, Niels; Gu, Yu-Mei; Broer, Linda; Ham, Annelies C; Hansen, Torben; Harris, Tamara B; Hartman, Catharina A; Hassinen, Maija; Hastie, Nicholas; Hattersley, Andrew T; Heath, Andrew C; Henders, Anjali K; Hernandez, Dena; Hillege, Hans; Holmen, Oddgeir; Hovingh, Kees G; Hui, Jennie; Husemoen, Lise L; Hutri-Kahonen, Nina; Hysi, Pirro G; Illig, Thomas; De Jager, Philip L; Jalilzadeh, Shapour; Jorgensen, Torben; Jukema, J Wouter; Juonala, Markus; Kanoni, Stavroula; Karaleftheri, Maria; Khaw, Kay Tee; Kinnunen, Leena; Kittner, Steven J; Koenig, Wolfgang; Kolcic, Ivana; Kovacs, Peter; Krarup, Nikolaj T; Kratzer, Wolfgang; Kruger, Janine; Kuh, Diana; Kumari, Meena; Kyriakou, Theodosios; Langenberg, Claudia; Lannfelt, Lars; Lanzani, Chiara; Lotay, Vaneet; Launer, Lenore J; Leander, Karin; Lindstrom, Jaana; Linneberg, Allan; Liu, Yan-Ping; Lobbens, Stephane; Luben, Robert; Lyssenko, Valeriya; Mannisto, Satu; Magnusson, Patrik K; McArdle, Wendy L; Menni, Cristina; Merger, Sigrun; Milani, Lili; Montgomery, Grant W; Morris, Andrew P; Narisu, Narisu; Nelis, Mari; Ong, Ken K; Palotie, Aarno; Perusse, Louis; Pichler, Irene; Pilia, Maria G; Pouta, Anneli; Rheinberger, Myriam; Ribel-Madsen, Rasmus; Richards, Marcus; Rice, Kenneth M; Rice, Treva K; Rivolta, Carlo; Salomaa, Veikko; Sanders, Alan R; Sarzynski, Mark A; Scholtens, Salome; Scott, Robert A; Scott, William R; Sebert, Sylvain; Sengupta, Sebanti; Sennblad, Bengt; Seufferlein, Thomas; Silveira, Angela; Slagboom, P Eline; Smit, Jan H; Sparso, Thomas H; Stirrups, Kathleen; Stolk, Ronald P; Stringham, Heather M; Swertz, Morris A; Swift, Amy J; Syvanen, Ann-Christine; Tan, Sian-Tsung; Thorand, Barbara; Tonjes, Anke; Tremblay, Angelo; Tsafantakis, Emmanouil; van der Most, Peter J; Volker, Uwe; Vohl, Marie-Claude; Vonk, Judith M; Waldenberger, Melanie; Walker, Ryan W; Wennauer, Roman; Widen, Elisabeth; Willemsen, Gonneke; Wilsgaard, Tom; Wright, Alan F; Zillikens, M Carola; van Dijk, Suzanne C; van Schoor, Natasja M; Asselbergs, Folkert W; de Bakker, Paul I W; Beckmann, Jacques S; Beilby, John; Bennett, David A; Bergman, Richard N; Bergmann, Sven; Boger, Carsten A; Boehm, Bernhard O; Boerwinkle, Eric; Boomsma, Dorret I; Bornstein, Stefan R; Bottinger, Erwin P; Bouchard, Claude; Chambers, John C; Chanock, Stephen J; Chasman, Daniel I; Cucca, Francesco; Cusi, Daniele; Dedoussis, George; Erdmann, Jeanette; Eriksson, Johan G; Evans, Denis A; de Faire, Ulf; Farrall, Martin; Ferrucci, Luigi; Ford, Ian; Franke, Lude; Franks, Paul W; Froguel, Philippe; Gansevoort, Ron T; Gieger, Christian; Gronberg, Henrik; Gudnason, Vilmundur; Gyllensten, Ulf; Hall, Per; Hamsten, Anders; van der Harst, Pim; Hayward, Caroline; Heliovaara, Markku; Hengstenberg, Christian; Hicks, Andrew A; Hingorani, Aroon; Hofman, Albert; Hu, Frank; Huikuri, Heikki V; Hveem, Kristian; James, Alan L; Jordan, Joanne M; Jula, Antti; Kahonen, Mika; Kajantie, Eero; Kathiresan, Sekar; Kiemeney, Lambertus A L M; Kivimaki, Mika; Knekt, Paul B; Koistinen, Heikki A; Kooner, Jaspal S; Koskinen, Seppo; Kuusisto, Johanna; Maerz, Winfried; Martin, Nicholas G; Laakso, Markku; Lakka, Timo A; Lehtimaki, Terho; Lettre, Guillaume; Levinson, Douglas F; Lind, Lars; Lokki, Marja-Liisa; Mantyselka, Pekka; Melbye, Mads; Metspalu, Andres; Mitchell, Braxton D; Moll, Frans L; Murray, Jeffrey C; Musk, Arthur W; Nieminen, Markku S; Njolstad, Inger; Ohlsson, Claes; Oldehinkel, Albertine J; Oostra, Ben A; Palmer, Lyle J; Pankow, James S; Pasterkamp, Gerard; Pedersen, Nancy L; Pedersen, Oluf; Penninx, Brenda W; Perola, Markus; Peters, Annette; Polasek, Ozren; Pramstaller, Peter P; Psaty, Bruce M; Qi, Lu; Quertermous, Thomas; Raitakari, Olli T; Rankinen, Tuomo; Rauramaa, Rainer; Ridker, Paul M; Rioux, John D; Rivadeneira, Fernando; Rotter, Jerome I; Rudan, Igor; den Ruijter, Hester M; Saltevo, Juha; Sattar, Naveed; Schunkert, Heribert; Schwarz, Peter E H; Shuldiner, Alan R; Sinisalo, Juha; Snieder, Harold; Sorensen, Thorkild I A; Spector, Tim D; Staessen, Jan A; Stefania, Bandinelli; Thorsteinsdottir, Unnur; Stumvoll, Michael; Tardif, Jean-Claude; Tremoli, Elena; Tuomilehto, Jaakko; Uitterlinden, Andre G; Uusitupa, Matti; Verbeek, Andre L M; Vermeulen, Sita H; Viikari, Jorma S; Vitart, Veronique; Volzke, Henry; Vollenweider, Peter; Waeber, Gerard; Walker, Mark; Wallaschofski, Henri; Wareham, Nicholas J; Watkins, Hugh; Zeggini, Eleftheria; Chakravarti, Aravinda; Clegg, Deborah J; Cupples, L Adrienne; Gordon-Larsen, Penny; Jaquish, Cashell E; Rao, D C; Abecasis, Goncalo R; Assimes, Themistocles L; Barroso, Ines; Berndt, Sonja I; Boehnke, Michael; Deloukas, Panos; Fox, Caroline S; Groop, Leif C; Hunter, David J; Ingelsson, Erik; Kaplan, Robert C; McCarthy, Mark I; Mohlke, Karen L; O'Connell, Jeffrey R; Schlessinger, David; Strachan, David P; Stefansson, Kari; van Duijn, Cornelia M; Hirschhorn, Joel N; Lindgren, Cecilia M; Heid, Iris M; North, Kari E; Borecki, Ingrid B; Kutalik, Zoltan; Loos, Ruth J F/titolo:The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study./doi:10.1371%2Fjournal.pgen.1005378/rivista:PLOS genetics (Online)/anno:2015/pagina_da:e1005378/pagina_a:/intervallo_pagine:e1005378/volume:11, PLoS Genetics, 11(10), PLoS genetics, 11(10). Public Library of Science, Plos Genetics, 11(10):e1005378. Public Library of Science, Winkler, T W, Justice, A E, Graff, M, Barata, L, Feitosa, M F, Chu, S, Czajkowski, J, Esko, T, Fall, T, Kilpelainen, T O, Lu, Y, Magi, R, Mihailov, E, Pers, T H, Rueeger, S, Teumer, A, Ehret, G B, Ferreira, T, Heard-Costa, N L, Karjalainen, J, Lagou, V, Mahajan, A, Neinast, M D, Prokopenko, I, Simino, J, Teslovich, T M, Jansen, R, Westra, H, White, C C, Absher, D, Ahluwalia, T S, Ahmad, S, Albrecht, E, Alves, A C, Bragg-Gresham, J L, Craen, A J M, Bis, J C, Bonnefond, A, Boucher, G, Cadby, G, Cheng, Y, Chiang, C W K, Delgado, G, Demirkan, A, Dueker, N, Eklund, N, Eiriksdottir, G, Eriksson, J, Feenstra, B, Fischer, K, Frau, F, Galesloot, T E, Geller, F, Goel, A, Gorski, M, Grammer, T B, Gustafsson, S, Haitjema, S, Hottenga, J J, Huffman, J E, Jackson, A U, Jacobs, K B, Johansson, A, Kaakinen, M, Kleber, M E, Lahti, J, Leach, I M, Lehne, B, Lo, K S, Lorentzon, M, Luan, J, Madden, P A F, Mangino, M, McKnight, B, Medina-Gomez, C, Monda, K L, Montasser, M E, Mueller, G, Mueller-Nurasyid, M, Nolte, I M, Panoutsopoulou, K, Pascoe, L, Paternoster, L, Rayner, N W, Renstrom, F, Rizzi, F, Rose, L M, Ryan, K A, Salo, P, Sanna, S, Scharnagl, H, Shi, J, Smith, A V, Southam, L, Stancakova, A, Steinthorsdottir, V, Strawbridge, R J, Sung, Y J, Tachmazidou, I, Tanaka, T, Thorleifsson, G, Trompet, S, Pervjakova, N, Tyrer, J P, Vandenput, L, van der Laan, S W, van der Velde, N, van Setten, J, van Vliet-Ostaptchouk, J V, Verweij, N, Vlachopoulou, E, Waite, L L, Wang, S R, Wang, Z, Wild, S H, Willenborg, C, Wilson, J F, Wong, A, Yang, J, Yengo, L, Yerges-Armstrong, L M, Yu, L, Zhang, W, Zhao, J H, Andersson, E A, Bakker, S J L, Baldassarre, D, Banasik, K, Barcella, M, Barlassina, C, Bellis, C, Benaglio, P, Blangero, J, Blueher, M, Bonnet, F, Bonnycastle, L L, Boyd, H A, Bruinenberg, M, Buchman, A S, Campbell, H, Chen, Y I, Chines, P S, Claudi-Boehm, S, Cole, J, Collins, F S, de Geus, E J C, de Groot, L C P G M, Dimitriou, M, Duan, J, Enroth, S, Eury, E, Farmaki, A, Forouhi, N G, Friedrich, N, Gejman, P V, Gigante, B, Glorioso, N, Go, A S, Gottesman, O, Graessler, J, Grallert, H, Grarup, N, Gu, Y, Broer, L, van der Ham, A C, Hansen, T, Harris, T B, Hartman, C A, Hassinen, M, Hastie, N, Hattersley, A T, Heath, A C, Henders, A K, Hernandez, D, Hillege, H, Holmen, O, Hovingh, K G, Hui, J, Husemoen, L L, Hutri-Kahonen, N, Hysi, P G, Illig, T, de Jager, P L, Jalilzadeh, S, Jorgensen, T, Jukema, J W, Juonala, M, Kanoni, S, Karaleftheri, M, Khaw, K T, Kinnunen, L, Kittner, S J, Koenig, W, Kolcic, I, Kovacs, P, Krarup, N T, Kratzer, W, Krueger, J, Kuh, D, Kumari, M, Kyriakou, T, Langenberg, C, Lannfelt, L, Lanzani, C, Lotay, V, Launer, L J, Leander, K, Lindstrom, J, Linneberg, A, Liu, Y, Lobbens, S, Luben, R, Lyssenko, V, Mannisto, S, Magnusson, P K, McArdle, W L, Menni, C, Merger, S, Milani, L, Montgomery, G W, Morris, A P, Narisu, N, Nelis, M, Ong, K K, Palotie, A, Perusse, L, Pichler, I, Pilia, M G, Pouta, A, Rheinberger, M, Ribel-Madsen, R, Richards, M, Rice, K M, Rice, T K, Rivolta, C, Salomaa, V, Sanders, A R, Sarzynski, M A, Scholtens, S, Scott, R A, Scott, W R, Sebert, S, Sengupta, S, Sennblad, B, Seufferlein, T, Silveira, A, Slagboom, P E, Smit, J H, Sparso, T H, Stirrups, K, Stolk, R P, Stringham, H M, Swertz, M A, Swift, A J, Syvanen, A, Tan, S, Thorand, B, Toenjes, A, Tremblay, A, Tsafantakis, E, van der Most, P J, Voelker, U, Vohl, M, Vonk, J M, Waldenberger, M, Walker, R W, Wennauer, R, Widen, E, Willemsen, G, Wilsgaard, T, Wright, A F, Zillikens, M C, van Dijk, S C, van Schoor, N M, Asselbergs, F W, Bakker, P I W, Beckmann, J S, Beilby, J, Bennett, D A, Bergman, R N, Bergmann, S, Boeger, C A, Boehm, B O, Boerwinkle, E, Boomsma, D I, Bornstein, S R, Bottinger, E P, Bouchard, C, Chambers, J C, Chanock, S J, Chasman, D I, Cucca, F, Cusi, D, Dedoussis, G, Erdmann, J, Eriksson, J G, Evans, D A, de Faire, U, Farrall, M, Ferrucci, L, Ford, I, Franke, L, Franks, P W, Froguel, P, Gansevoort, R T, Gieger, C, Gronberg, H, Gudnason, V, Gyllensten, U, Hall, P, Hamsten, A, van der Harst, P, Hayward, C, Heliovaara, M, Hengstenberg, C, Hicks, A A, Hingorani, A, Hofman, A, Hu, F, Huikuri, H V, Hveem, K, James, A L, Jordan, J M, Jula, A, Kaehoenen, M, Kajantie, E, Kathiresan, S, Kiemeney, L A L M, Kivimaki, M, Knekt, P B, Koistinen, H A, Kooner, J S, Koskinen, S, Kuusisto, J, Maerz, W, Martin, N G, Laakso, M, Lakka, T A, Lehtimaki, T, Lettre, G, Levinson, D F, Lind, L, Lokki, M, Mantyselka, P, Melbye, M, Metspalu, A, Mitchell, B D, Moll, F L, Murray, J C, Musk, A W, Nieminen, M S, Njolstad, I, Ohlsson, C, Oldehinkel, A J, Oostra, B A, Palmer, L J, Pankow, J S, Pasterkamp, G, Pedersen, N L, Pedersen, O, Penninx, B W J H, Perola, M, Peters, A, Polasek, O, Pramstaller, P P, Psaty, B M, Qi, L, Quertermous, T, Raitakari, O T, Rankinen, T, Rauramaa, R, Ridker, P M, Rioux, J D, Rivadeneira, F, Rotter, J I, Rudan, I, den Ruijter, H M, Saltevo, J, Sattar, N, Schunkert, H, Schwarz, P E H, Shuldiner, A R, Sinisalo, J, Snieder, H, Sorensen, T I A, Spector, T D, Staessen, J A, Stefania, B, Thorsteinsdottir, U, Stumvoll, M, Tardif, J, Tremoli, E, Tuomilehto, J, Uitterlinden, A G, Uusitupa, M, Verbeek, A L M, Vermeulen, S H, Viikari, J S, Vitart, V, Voelzke, H, Vollenweider, P, Waeber, G, Walker, M, Wallaschofski, H, Wareham, N J, Watkins, H, Zeggini, E, Chakravarti, A, Clegg, D J, Cupples, L A, Gordon-Larsen, P, Jaquish, C E, Rao, D C, Abecasis, G R, Assimes, T L, Barroso, I, Berndt, S I, Boehnke, M, Deloukas, P, Fox, C S, Groop, L C, Hunter, D J, Ingelsson, E, Kaplan, R C, McCarthy, M I, Mohlke, K L, O'Connell, J R, Schlessinger, D, Strachan, D P, Stefansson, K, van Duijn, C M, Hirschhorn, J N, Lindgren, C M, Heid, I M, North, K E, Borecki, I B, Kutalik, Z & Loos, R J F 2015, ' The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study ', PLoS Genetics, vol. 11, no. 10, e1005378 . https://doi.org/10.1371/journal.pgen.1005378, PLOS Genetics, Vol. 11, No 10 (2015) P. e1005378, Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid, Consejería de Sanidad de la Comunidad de Madrid, PLoS Genetics, 2015, 11 (10), pp.e1005378. ⟨10.1371/journal.pgen.1005378⟩, PLoS Genetics, Vol 12, Iss 6, p e1006166 (2016), Plos Genetics, vol. 11, no. 10, pp. e1005378, PLoS Genetics; 11(10), no e1005378 (2015), PLoS Genetics (online), 11(10). Public Library of Science, PLoS Genetics, Vol 11, Iss 10, p e1005378 (2015)
- Publication Year :
- 2014
-
Abstract
- Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body size and shape change as people grow older and these changes differ substantially between men and women. To systematically screen for age- and/or sex-specific effects of genetic variants on BMI and WHRadjBMI, we performed meta-analyses of 114 studies (up to 320,485 individuals of European descent) with genome-wide chip and/or Metabochip data by the Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Each study tested the association of up to ~2.8M SNPs with BMI and WHRadjBMI in four strata (men ≤50y, men >50y, women ≤50y, women >50y) and summary statistics were combined in stratum-specific meta-analyses. We then screened for variants that showed age-specific effects (G x AGE), sex-specific effects (G x SEX) or age-specific effects that differed between men and women (G x AGE x SEX). For BMI, we identified 15 loci (11 previously established for main effects, four novel) that showed significant (FDR<br />Author Summary Adult body size and body shape differ substantially between men and women and change over time. More than 100 genetic variants that influence body mass index (measure of body size) or waist-to-hip ratio (measure of body shape) have been identified. While there is evidence that some genetic loci affect body shape differently in men than in women, little is known about whether genetic effects differ in older compared to younger adults, and whether such changes differ between men and women. Therefore, we conducted a systematic genome-wide search, including 114 studies (>320,000 individuals), to specifically identify genetic loci with age- and or sex-dependent effects on body size and shape. We identified 15 loci of which the effect on BMI was different in older compared to younger adults, whereas we found no evidence for loci with different effects in men compared to women. The opposite was seen for body shape as we identified 44 loci of which the effect on waist-to-hip ratio differed between men and women, but no difference between younger and older adults were observed. Our observations may provide new insights into the biology that underlies weight change with age or the sexual dimorphism of body shape.
- Subjects :
- 0301 basic medicine
Netherlands Twin Register (NTR)
Male
Cancer Research
endocrine system diseases
Biological pathways
QH426-470
Genome
Body Mass Index
Body Size
Genetics (clinical)
ddc:616
Genetics & Heredity
Sex Characteristics
Loci
MAGIC Consortium
Mass index
Age Factors
Chromosome Mapping
Middle Aged
Genealogy
Self-reported height
Peripheral-blood
Scale (social sciences)
ICBP Consortium
Female
Life Sciences & Biomedicine
Medical Genetics
Research Article
arcOGEN Consortium
musculoskeletal diseases
Adult
European Continental Ancestry Group
Natural menopause
Aged
Body Size/genetics
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Polymorphism, Single Nucleotide
Waist-Hip Ratio
Biology
Body size
DIAGRAM Consortium
Age and sex
White People
Fat distribution
GLGC Consortium
03 medical and health sciences
Life-course
Genetics
Weight-gain
Molecular Biology
Ecology, Evolution, Behavior and Systematics
Medicinsk genetik
[SDV.GEN]Life Sciences [q-bio]/Genetics
0604 Genetics
Science & Technology
nutritional and metabolic diseases
Correction
030104 developmental biology
GWAS meta-analysis
Global-BPGen Consortium
Common SNPS
CHARGE Consortium
3111 Biomedicine
Developmental Biology
Subjects
Details
- ISSN :
- 15537404 and 15537390
- Volume :
- 11
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- PLoS genetics
- Accession number :
- edsair.doi.dedup.....48d6f5f932496e7163246968cbc949bc
- Full Text :
- https://doi.org/10.1371/journal.pgen.1005378⟩