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Puerarin Attenuates Cadmium-Induced Neuronal Injury via Stimulating Cadmium Excretion, Inhibiting Oxidative Stress and Apoptosis

Authors :
Hui Zou
Yan Yuan
Li Wang
Jianchun Bian
Ruilong Song
Zongping Liu
Jianhong Gu
Shuangquan Wen
Source :
Biomolecules, Volume 11, Issue 7, Biomolecules, Vol 11, Iss 978, p 978 (2021)
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

Cadmium (Cd) is a potential pathogenic factor in the nervous system associated with various neurodegenerative disorders. Puerarin (Pur) is an isoflavone purified from the Chinese medical herb, kudzu root, and exhibits antioxidant and antiapoptotic properties in the brain. In this study, the detailed mechanisms underlying the neuroprotective potential of Pur against Cd-induced neuronal injury was evaluated for the first time in vivo in a rat model and in vitro using primary rat cerebral cortical neurons. The results of the in vivo experiments showed that Pur ameliorated Cd-induced neuronal injury, reduced Cd levels in the cerebral cortices, and stimulated Cd excretion in Cd-treated rats. We also observed that the administration of Pur rescued Cd-induced oxidative stress, and attenuated Cd-induced apoptosis by concomitantly suppressing both the Fas/FasL and mitochondrial pathways in the cerebral cortical neurons of rats both in vivo and in vitro. Our results demonstrate that Pur exerted its neuroprotective effects by stimulating Cd excretion, ameliorating Cd-induced oxidative stress and apoptosis in rat cerebral cortical neurons.

Details

ISSN :
2218273X
Volume :
11
Database :
OpenAIRE
Journal :
Biomolecules
Accession number :
edsair.doi.dedup.....4904533da8bde3bd6805130bbe189c61
Full Text :
https://doi.org/10.3390/biom11070978