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Puerarin Attenuates Cadmium-Induced Neuronal Injury via Stimulating Cadmium Excretion, Inhibiting Oxidative Stress and Apoptosis
- Source :
- Biomolecules, Volume 11, Issue 7, Biomolecules, Vol 11, Iss 978, p 978 (2021)
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Cadmium (Cd) is a potential pathogenic factor in the nervous system associated with various neurodegenerative disorders. Puerarin (Pur) is an isoflavone purified from the Chinese medical herb, kudzu root, and exhibits antioxidant and antiapoptotic properties in the brain. In this study, the detailed mechanisms underlying the neuroprotective potential of Pur against Cd-induced neuronal injury was evaluated for the first time in vivo in a rat model and in vitro using primary rat cerebral cortical neurons. The results of the in vivo experiments showed that Pur ameliorated Cd-induced neuronal injury, reduced Cd levels in the cerebral cortices, and stimulated Cd excretion in Cd-treated rats. We also observed that the administration of Pur rescued Cd-induced oxidative stress, and attenuated Cd-induced apoptosis by concomitantly suppressing both the Fas/FasL and mitochondrial pathways in the cerebral cortical neurons of rats both in vivo and in vitro. Our results demonstrate that Pur exerted its neuroprotective effects by stimulating Cd excretion, ameliorating Cd-induced oxidative stress and apoptosis in rat cerebral cortical neurons.
- Subjects :
- Male
0301 basic medicine
Nervous system
cadmium
Pharmacology
medicine.disease_cause
Microbiology
Biochemistry
Neuroprotection
Article
Fas ligand
Rats, Sprague-Dawley
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Puerarin
In vivo
medicine
Animals
oxidative stress
Molecular Biology
Cerebral Cortex
Neurons
cadmium excretion
Chemistry
apoptosis
puerarin
Isoflavones
QR1-502
In vitro
Rats
Neuroprotective Agents
030104 developmental biology
medicine.anatomical_structure
Apoptosis
030217 neurology & neurosurgery
Oxidative stress
Subjects
Details
- ISSN :
- 2218273X
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Biomolecules
- Accession number :
- edsair.doi.dedup.....4904533da8bde3bd6805130bbe189c61
- Full Text :
- https://doi.org/10.3390/biom11070978