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Twenty-Four-Hour Central (Aortic) Systolic Blood Pressure: Reference Values and Dipping Patterns in Untreated Individuals

Authors :
Weber, Thomas
Protogerou, Athanase D
Agharazii, Mohsen
Argyris, Antonis
Aoun Bahous, Sola
Banegas, Jose R
Binder, Ronald K
Blacher, Jacques
Araujo Brandao, Andréa
Cruz, Juan J
Danninger, Kathrin
Giannatasio, Cristina
Graciani, Auxiliadora
Hametner, Bernhard
Jankowski, Piotr
Li, Yan
Maloberti, Alessandro
Mayer, Christopher C
McDonnell, Barry J
McEniery, Carmel M
Antonio Mota Gomes, Marco
Machado Gomes, Annelise
Lorenza Muiesan, Maria
Nemcsik, Janos
Paini, Anna
Rodilla, Enrique
Schutte, Aletta E
Sfikakis, Petros P
Terentes-Printzios, Dimitrios
Vallée, Alexandre
Vlachopoulos, Charalambos
Ware, Lisa
Wilkinson, Ian
Zweiker, Robert
Sharman, James E
Wassertheurer, Siegfried
International Academic 24-Hour Ambulatory Aortic Blood Pressure Consortium (I24abc.Org)
Weber, Thomas [0000-0003-0617-0417]
Argyris, Antonis [0000-0002-8906-6959]
Banegas, Jose R [0000-0001-6152-9862]
Hametner, Bernhard [0000-0003-2048-1019]
Jankowski, Piotr [0000-0001-6223-8821]
Maloberti, Alessandro [0000-0002-2612-6264]
McDonnell, Barry J [0000-0001-5912-1278]
Antonio Mota Gomes, Marco [0000-0002-6652-1533]
Machado Gomes, Annelise [0000-0001-9475-3166]
Lorenza Muiesan, Maria [0000-0002-4007-9441]
Terentes-Printzios, Dimitrios [0000-0003-4039-8263]
Vlachopoulos, Charalambos [0000-0002-9904-3558]
Sharman, James E [0000-0003-2792-0811]
Apollo - University of Cambridge Repository
Publication Year :
2022
Publisher :
Ovid Technologies (Wolters Kluwer Health), 2022.

Abstract

Central (aortic) systolic blood pressure (cSBP) is the pressure seen by the heart, the brain, and the kidneys. If properly measured, cSBP is closer associated with hypertension-mediated organ damage and prognosis, as compared with brachial SBP (bSBP). We investigated 24-hour profiles of bSBP and cSBP, measured simultaneously using Mobilograph devices, in 2423 untreated adults (1275 women; age, 18-94 years), free from overt cardiovascular disease, aiming to develop reference values and to analyze daytime-nighttime variability. Central SBP was assessed, using brachial waveforms, calibrated with mean arterial pressure (MAP)/diastolic BP (cSBPMAP/DBPcal), or bSBP/diastolic blood pressure (cSBPSBP/DBPcal), and a validated transfer function, resulting in 144 509 valid brachial and 130 804 valid central measurements. Averaged 24-hour, daytime, and nighttime brachial BP across all individuals was 124/79, 126/81, and 116/72 mm Hg, respectively. Averaged 24-hour, daytime, and nighttime values for cSBPMAP/DBPcal were 128, 128, and 125 mm Hg and 115, 117, and 107 mm Hg for cSBPSBP/DBPcal, respectively. We pragmatically propose as upper normal limit for 24-hour cSBPMAP/DBPcal 135 mm Hg and for 24-hour cSBPSBP/DBPcal 120 mm Hg. bSBP dipping (nighttime-daytime/daytime SBP) was -10.6 % in young participants and decreased with increasing age. Central SBPSBP/DBPcal dipping was less pronounced (-8.7% in young participants). In contrast, cSBPMAP/DBPcal dipping was completely absent in the youngest age group and less pronounced in all other participants. These data may serve for comparison in various diseases and have potential implications for refining hypertension diagnosis and management. The different dipping behavior of bSBP versus cSBP requires further investigation.

Details

Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....49159d25bf3903f7df4fdc08ac848ad7
Full Text :
https://doi.org/10.17863/cam.79775