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Living donor vs. deceased donor liver transplantation for patients with hepatitis C virus-related diseases
- Source :
- Journal of hepatology. 57(6)
- Publication Year :
- 2012
-
Abstract
- Background & Aims Living donor liver transplantation (LDLT) provides a timely alternative to deceased donor liver transplantation (DDLT) for patients with hepatitis C virus-related (HCV-related) diseases in the circumstances of severe organ dearth. However, the patient and graft outcomes, and recurrence of HCV after LDLT remain controversial. Here we sought to compare the post-transplant outcomes after LDLT and DDLT. Methods A systematic review and meta-analysis were performed. PubMed/MEDLINE, EMBASE, and the Cochrane database were searched for eligible literatures. The major end points were patient survival, graft survival, recurrence rate, and acute rejection. The pooled odds ratio (OR) was calculated using random-effects model to synthesize the results. Heterogeneity and publication bias were quantitatively evaluated. Results Fourteen studies with a total of 2024 participants were included in this analysis. We found comparable patient survival between groups (1-year: OR, 0.78, 95% CI, 0.48–1.26, p= 0.31; 2-year: OR, 0.71, 95% CI, 0.41–1.23, p= 0.23; 3-year: OR, 0.79, 95% CI, 0.5–1.12, p= 0.18; 4-year: OR, 0.92, 95% CI, 0.43–1.95, p= 0.83; 5-year: OR, 1.06, 95% CI, 0.53–2.14, p= 0.86, respectively). Although 1- and 3-year graft survivals were inferior in LDLT, 2-, 4- and 5-year graft survivals were similar. HCV recurrence rates and acute rejection rates were equivalent. Conclusions LDLT was equivalent to DDLT in terms of patient survival, long-term graft survival, HCV recurrence, and acute rejection rates, with potentially lower short-term patient and graft survival.
- Subjects :
- Graft Rejection
medicine.medical_specialty
medicine.medical_treatment
Hepatitis C virus
MEDLINE
Liver transplantation
medicine.disease_cause
Gastroenterology
Recurrence
Internal medicine
medicine
Cadaver
Living Donors
Humans
Hepatology
business.industry
Graft Survival
Odds ratio
Publication bias
Hepatitis C
medicine.disease
Confidence interval
Surgery
Liver Transplantation
Meta-analysis
business
Publication Bias
Subjects
Details
- ISSN :
- 16000641
- Volume :
- 57
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Journal of hepatology
- Accession number :
- edsair.doi.dedup.....491a39e1f7b39ccc26aab5c0b85e7d90