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Hospital discharges in urban sanitation systems: Long-term monitoring of wastewater resistome and microbiota in relationship to their eco-exposome
- Source :
- Water Research X, Water Research X, 2020, 7, pp.100045. ⟨10.1016/j.wroa.2020.100045⟩, Repositorio Institucional del Instituto IMDEA Agua, Instituto IMDEA Agua (IMDEA AGUA), Water Research X, Elsevier, 2020, 7, pp.100045. ⟨10.1016/j.wroa.2020.100045⟩, Water Research X, Vol 7, Iss, Pp-(2020), instname
- Publication Year :
- 2020
- Publisher :
- HAL CCSD, 2020.
-
Abstract
- Wastewaters (WW) are important sources for the dissemination of antimicrobial resistance (AMR) into the environment. Hospital WW (HWW) contain higher loads of micro-pollutants and AMR markers than urban WW (UWW). Little is known about the long-term dynamics of H and U WW and the impact of their joined treatment on the general burden of AMR. Here, we characterized the resistome, microbiota and eco-exposome signature of 126 H and U WW samples treated separately for three years, and then mixed, over one year. Multi-variate analysis and machine learning revealed a robust signature for each WW with no significant variation over time before mixing, and once mixed, both WW closely resembled Urban signatures. We demonstrated a significant impact of pharmaceuticals and surfactants on the resistome and microbiota of H and U WW. Our results present considerable targets for AMR related risk assessment of WW.<br />Graphical abstract Image 1<br />Highlights • Hospital and urban wastewater resistome and microbiota display specific signatures stable over time. • Hospital and urban wastewater have a distinct eco-exposome that is associated with their respective resistome and microbiota. • Mixing hospital with urban wastewater hides the " hospital signature” due to the dilution rate.
- Subjects :
- Sanitation
010501 environmental sciences
Wastewater
Antimicrobial resistance
01 natural sciences
AMR
lcsh:Environmental technology. Sanitary engineering
HWW
Waste Management and Disposal
Water Science and Technology
0303 health sciences
WW signatures
Full Paper
Ecological Modeling
Microbiota
ARG
Resistome (ARGs and MGEs)
ARB
WW
Pollution
6. Clean water
WW, Wastewater
Hospital Wastewater
Urban Wastewater
GE Environmental Sciences
Exposome
Biology
lcsh:TD1-1066
03 medical and health sciences
Hospital and urban wastewater eco-exposome
Environmental health
Antibiotic-Resistant Gene
ARB, Antibiotic-Resistant Bacteria
Mobile Genetic Element
030304 developmental biology
0105 earth and related environmental sciences
Hospital and urban wastewater
HWW, Hospital Wastewater
MGE, Mobile Genetic Element
MGE
UWW
Antibiotic-Resistant Bacteria
[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
AMR, Antimicrobial Resistance
Resistome
[SDE.BE] Environmental Sciences/Biodiversity and Ecology
Long term monitoring
UWW, Urban Wastewater
[SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
[SDE.BE]Environmental Sciences/Biodiversity and Ecology
ARG, Antibiotic-Resistant Gene
Subjects
Details
- Language :
- English
- ISSN :
- 25899147
- Database :
- OpenAIRE
- Journal :
- Water Research X, Water Research X, 2020, 7, pp.100045. ⟨10.1016/j.wroa.2020.100045⟩, Repositorio Institucional del Instituto IMDEA Agua, Instituto IMDEA Agua (IMDEA AGUA), Water Research X, Elsevier, 2020, 7, pp.100045. ⟨10.1016/j.wroa.2020.100045⟩, Water Research X, Vol 7, Iss, Pp-(2020), instname
- Accession number :
- edsair.doi.dedup.....492ee82254101c165d806a39ba5299f1