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Reliability of Selected Antioxidants and Compounds Involved in One-Carbon Metabolism in Two Dutch Cohorts
- Source :
- Nutrition and Cancer 65 (2013) 1, Nutrition and Cancer-An International Journal, 65, 17-24, Nutrition and Cancer, 65(1), 17-24, Nutrition and Cancer-An International Journal, 65, 1, pp. 17-24, Nutrition and Cancer, 65(1), 17. Routledge
- Publication Year :
- 2013
-
Abstract
- Contains fulltext : 117571.pdf (Publisher’s version ) (Closed access) Many epidemiological studies assess nutritional status based on single blood measurements, without verifying if these remain reliable over repeated measurements. This study assessed the reliability over a period of 2 to 5 yr of plasma carotenoids, vitamin C, retinol, tocopherols, and serum compounds involved in 1-carbon metabolism in a subsample of Dutch participants of European Prospective Investigation into Cancer and Nutrition (EPIC). Blood samples from 38 men from MORGEN-EPIC and 35 women from Prospect-EPIC were collected between 1993 and 1997 and again after 2 to 5 yr. The reliability of plasma carotenoids, retinol, vitamin C, and tocopherols, and of serum folate, homocysteine, and vitamins B6 and B12 was estimated using an intraclass correlation coefficient (ICC). Serum homocysteine and vitamin B12 were highly reliable biomarkers, with ICCs of 0.91 and 0.75, respectively. All other analyzed biomarkers had a slight or fair reliability over several years (ICCs ranged from 0.17 to 0.56). Most examined biomarkers showed reliability values that may lead to considerable attenuation of the risk estimate when used as exposure assessment in a risk model. If multiple measurements are not available, the risk estimates can be adjusted for the regression dilution using the ICC as adjustment coefficient.
- Subjects :
- Male
Cancer Research
Homocysteine
Nutrition and Disease
Intraclass correlation
design
Physiology
Tocopherols
Medicine (miscellaneous)
Ascorbic Acid
Wiskundige en Statistische Methoden - Biometris
Antioxidants
Cohort Studies
chemistry.chemical_compound
c-reactive protein
Voeding en Ziekte
oxidative stress
Vitamin A
Netherlands
Nutrition and Dietetics
Chemistry
Retinol
carotenoids
Middle Aged
tocopherol
European Prospective Investigation into Cancer and Nutrition
Vitamin B 12
Oncology
Female
retinol
Adult
Regression dilution
Nutritional Status
nutritional biomarkers
Young Adult
Folic Acid
Humans
cancer
Vitamin B12
Mathematical and Statistical Methods - Biometris
Aged
Molecular epidemiology Aetiology, screening and detection [NCEBP 1]
Vitamin C
Carbon
Vitamin B 6
Diet
Risk Estimate
Immunology
plasma homocysteine
serum
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 01635581
- Database :
- OpenAIRE
- Journal :
- Nutrition and Cancer 65 (2013) 1, Nutrition and Cancer-An International Journal, 65, 17-24, Nutrition and Cancer, 65(1), 17-24, Nutrition and Cancer-An International Journal, 65, 1, pp. 17-24, Nutrition and Cancer, 65(1), 17. Routledge
- Accession number :
- edsair.doi.dedup.....4944738746a47c4f7297bf7a1ed28239