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The fatty acid-binding protein-2 A54T polymorphism is associated with renal disease in patients with type 2 diabetes

Authors :
Clarissa Capp
Kátia Gonçalves dos Santos
Israel Roisemberg
Luis Henrique Santos Canani
Ana Luiza Maia
Gustavo Baldino Nabinger
Daisy Crispim
Jorge Luiz Gross
Andrzej S. Krolewski
Daniel P.K. Ng
Serena G.L. Choo
Source :
Diabetes. 54(11)
Publication Year :
2005

Abstract

The intestinal fatty–acid binding protein-2 (FABP2) gene codes a protein responsible for the absorption of long-chain fatty acids. To test whether FABP2 is a candidate gene for renal disease in patients with type 2 diabetes, a functional A54T polymorphism was genotyped in 1,042 Brazilians with type 2 diabetes. Patients were classified as having normoalbuminuria (urinary albumin excretion [UAE] 199 μg/min; n = 160). Patients with end-stage renal disease (ESRD) (n = 136) were also included. The prevalence of the TT genotype was higher in patients with renal involvement compared with those with normoalbuminuria (odds ratio [95% CI] 2.4 [1.1–5.4]) following adjustment for type 2 diabetes duration, BMI, hypertension, A1C, and cholesterol levels. The risk was similar considering different stages of renal involvement. In a second independent patient sample (483 type 2 diabetic Caucasians residing in Massachusetts), a significant association was also observed between the TT genotype and proteinuria or ESRD (2.7 [1.0–7.3]; P = 0.048). This study thus provides evidence that FABP2 confers susceptibility to renal disease in type 2 diabetic patients.

Details

ISSN :
00121797
Volume :
54
Issue :
11
Database :
OpenAIRE
Journal :
Diabetes
Accession number :
edsair.doi.dedup.....494d36e8df094fc642f15a164d623f61