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The fatty acid-binding protein-2 A54T polymorphism is associated with renal disease in patients with type 2 diabetes
- Source :
- Diabetes. 54(11)
- Publication Year :
- 2005
-
Abstract
- The intestinal fatty–acid binding protein-2 (FABP2) gene codes a protein responsible for the absorption of long-chain fatty acids. To test whether FABP2 is a candidate gene for renal disease in patients with type 2 diabetes, a functional A54T polymorphism was genotyped in 1,042 Brazilians with type 2 diabetes. Patients were classified as having normoalbuminuria (urinary albumin excretion [UAE] 199 μg/min; n = 160). Patients with end-stage renal disease (ESRD) (n = 136) were also included. The prevalence of the TT genotype was higher in patients with renal involvement compared with those with normoalbuminuria (odds ratio [95% CI] 2.4 [1.1–5.4]) following adjustment for type 2 diabetes duration, BMI, hypertension, A1C, and cholesterol levels. The risk was similar considering different stages of renal involvement. In a second independent patient sample (483 type 2 diabetic Caucasians residing in Massachusetts), a significant association was also observed between the TT genotype and proteinuria or ESRD (2.7 [1.0–7.3]; P = 0.048). This study thus provides evidence that FABP2 confers susceptibility to renal disease in type 2 diabetic patients.
- Subjects :
- medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Type 2 diabetes
urologic and male genital diseases
Fatty Acid-Binding Proteins
Nephropathy
chemistry.chemical_compound
Internal medicine
Genotype
Internal Medicine
medicine
Odds Ratio
Humans
Diabetic Nephropathies
Genetic Predisposition to Disease
Proteinuria
Polymorphism, Genetic
business.industry
Cholesterol
Odds ratio
medicine.disease
Endocrinology
chemistry
Diabetes Mellitus, Type 2
Haplotypes
Massachusetts
Microalbuminuria
medicine.symptom
business
Brazil
Kidney disease
Subjects
Details
- ISSN :
- 00121797
- Volume :
- 54
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Diabetes
- Accession number :
- edsair.doi.dedup.....494d36e8df094fc642f15a164d623f61