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Mn(II)-Based Lipidic Nanovesicles as High-Efficiency MRI Probes

Authors :
Gabriele A. Rolla
Mauro Botta
Lorenzo Tei
Enzo Terreno
Lucas W. E. Starmans
Gilberto Mulas
Carlos F. G. C. Geraldes
Publication Year :
2020

Abstract

Although nowadays there is a renewed and growing interest in Mn-based contrast agents, there are only few studies dealing with Mn-based lipophilic nanoparticles and how they may be optimized as MRI contrast agents. Three amphiphilic paramagnetic Mn(II) complexes based on derivatives of EDTA and 1,4-DO2A were used for the preparation of lipidic nanoparticles. The length and position of the aliphatic chains were found to control whether either vesicular liposomes, nonvesicular bicelles, or a mixture of both was produced as well as the size and morphology of phospholipid-based self-assembling nanoaggregates. These differences determine whether hydrophilic Gd-based contrast agents or fluorescent dyes can be entrapped in the aqueous core of the nanoaggregate. Structural characterization was performed by cryo-TEM. Detailed

Details

Language :
English
Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....4966dd935016ecff4a10fa2731ce894d