Back to Search
Start Over
Isolated +15 in bone marrow: disease-associated or a benign finding?
- Source :
- Leukemia research. 39(1)
- Publication Year :
- 2014
-
Abstract
- It has been controversial if trisomy 15 (+15) as an isolated clonal cytogenetic abnormality in bone marrow (BM) is disease-associated or a benign finding. To answer this question, we retrospectively reviewed our cytogenetic archives and identified 31 patients with isolated +15. Four patients presented with acute myeloid leukemia (AML), +15 was the major clone (56-95% of interphases) in BM and the clonal size of +15 was correlated with blast burden and disease status. For the remaining 27 patients, +15 was a minor clone (3-24% of interphases) in BM. Eighteen patients had a history of cytotoxic therapies and developed +15 after a median latency interval of 34 months. Six patients had BM involvement by lymphoma or myeloma, and +15 was exclusively detected in myeloid and erythroid cells, not in lymphoma or myeloma cells. With a median follow-up of 28 months, none of these 27 patients had clinical or morphological evidence of myelodysplastic syndromes. We conclude that +15 can be associated with AML, but more often isolated +15 presents as a minor clone in BM, and may not be disease associated. Clinical follow-up rather than an immediate therapeutic intervention seems most appropriate for non-leukemic patients with isolated +15.
- Subjects :
- Male
Cancer Research
Pathology
medicine.medical_specialty
Myeloid
Clone (cell biology)
Trisomy
Bone Marrow
hemic and lymphatic diseases
Medicine
Cytotoxic T cell
Humans
Clinical significance
Myeloid Cells
Lymphocytes
Aged
Chromosomes, Human, Pair 15
business.industry
Myelodysplastic syndromes
Myeloid leukemia
Hematology
Middle Aged
medicine.disease
Lymphoma
Leukemia, Myeloid, Acute
medicine.anatomical_structure
Oncology
Myelodysplastic Syndromes
Female
Bone marrow
business
Subjects
Details
- ISSN :
- 18735835
- Volume :
- 39
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Leukemia research
- Accession number :
- edsair.doi.dedup.....4981ce6e598b5cddc0ee305bc52d693e