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Ischemic burden assessment of myocardial perfusion CT, compared with SPECT using semi-quantitative and quantitative approaches
Ischemic burden assessment of myocardial perfusion CT, compared with SPECT using semi-quantitative and quantitative approaches
- Source :
- International Journal of Cardiology. 278:287-294
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Background We aimed to compare the myocardial ischemic burden assessed using semi-quantitative and quantitative analysis of computed tomography-myocardial perfusion imaging (CT-MPI) with that of single-photon emission computed tomography (SPECT). Methods From 2011 to 2013, 97 patients who underwent CT-MPI and SPECT were evaluated. The extent and severity of perfusion defects were assessed on a 5-point scale using a standard 16-segment model, and were expressed as summed stress score (SSS) and summed difference score (SDS). Receiver operating characteristic (ROC) curves for quantitative parameters were generated for the diagnosis of abnormal perfusion defect (SSS ≥ 4) and presence of ischemia (SDS ≥ 2) on SPECT. Results On CT-MPI, 298 (19.2%) of the 1552 segments showed perfusion abnormalities during stress, whereas perfusion abnormalities were shown in 179 (11.5%) segments on SPECT-MPI. On a per-person basis, there was good agreement, with intraclass correlation coefficients of 0.78 for SSS and 0.72 for SDS. A significant reduction of attenuation in stress and myocardial perfusion reserve index, along with an increase in % defect volume of CT-MPI, were demonstrated as the degree of perfusion defect or ischemia on SPECT increased. On the ROC curves, % defect volume on CT-MPI demonstrated the highest area under the curve: 0.91 for abnormal perfusion defect and 0.89 (all p Conclusions Semi-quantitative analysis of CT-MPI showed good accordance with SPECT. A quantitative approach for CT-MPI, especially % defect volume, may provide additional value in the identification of myocardial perfusion abnormalities. Clinical Trial Registration: https://clinicaltrials.gov/ct2/show/NCT01696006 .
- Subjects :
- Adult
Male
Myocardial Ischemia
Ischemia
Perfusion scanning
030204 cardiovascular system & hematology
Coronary artery disease
03 medical and health sciences
Myocardial perfusion imaging
0302 clinical medicine
Cost of Illness
medicine
Humans
030212 general & internal medicine
Aged
Retrospective Studies
Tomography, Emission-Computed, Single-Photon
medicine.diagnostic_test
Receiver operating characteristic
business.industry
Myocardial Perfusion Imaging
Middle Aged
medicine.disease
SSS
Female
Tomography, X-Ray Computed
Cardiology and Cardiovascular Medicine
Nuclear medicine
business
Perfusion
Emission computed tomography
Subjects
Details
- ISSN :
- 01675273
- Volume :
- 278
- Database :
- OpenAIRE
- Journal :
- International Journal of Cardiology
- Accession number :
- edsair.doi.dedup.....4987719a74023901b605dc8e7f08f05c
- Full Text :
- https://doi.org/10.1016/j.ijcard.2018.12.046