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Synthesis of an Uncharged Tetra-cyclopeptide Acting as a Transmembrane Carrier: Enhanced Cellular and Nuclear Uptake
Synthesis of an Uncharged Tetra-cyclopeptide Acting as a Transmembrane Carrier: Enhanced Cellular and Nuclear Uptake
- Source :
- Organic Letters, Vol. 19, No 3 (2017) pp. 612-615
- Publication Year :
- 2017
-
Abstract
- A small uncharged cyclopeptide scaffold inspired by a natural product and designed to undergo postfunctionalizations was used as a new transmembrane vector. A bioactive and fluorescent triazole aminocoumarin was bound to this carrier to facilitate its moving across cell and subcellular membranes, and this led to an increase in its cell toxicity.
- Subjects :
- Scaffold
Cell
Triazole
Nanotechnology
010402 general chemistry
01 natural sciences
Biochemistry
Peptides, Cyclic
chemistry.chemical_compound
medicine
Physical and Theoretical Chemistry
ddc:615
Natural product
biology
Molecular Structure
010405 organic chemistry
Organic Chemistry
Cell Membrane
biology.organism_classification
Fluorescence
Transmembrane protein
0104 chemical sciences
Membrane
medicine.anatomical_structure
chemistry
Biophysics
Tetra
Subjects
Details
- Language :
- English
- ISSN :
- 15237060
- Database :
- OpenAIRE
- Journal :
- Organic Letters, Vol. 19, No 3 (2017) pp. 612-615
- Accession number :
- edsair.doi.dedup.....499374aa90a4159699fff4c66596e28f