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Synthesis of an Uncharged Tetra-cyclopeptide Acting as a Transmembrane Carrier: Enhanced Cellular and Nuclear Uptake

Synthesis of an Uncharged Tetra-cyclopeptide Acting as a Transmembrane Carrier: Enhanced Cellular and Nuclear Uptake

Authors :
Yung-Sing Wong
Flaviane F. Hilário
Marjorie Maynadier
Vincent Zwick
Henri Vial
Rossimiriam Pereira de Freitas
Claudia A. Simões-Pires
Mohamed Dit Mady Traoré
Laurence Berry
Nicolas Fantozzi
Sharon Wein
Muriel Cuendet
Source :
Organic Letters, Vol. 19, No 3 (2017) pp. 612-615
Publication Year :
2017

Abstract

A small uncharged cyclopeptide scaffold inspired by a natural product and designed to undergo postfunctionalizations was used as a new transmembrane vector. A bioactive and fluorescent triazole aminocoumarin was bound to this carrier to facilitate its moving across cell and subcellular membranes, and this led to an increase in its cell toxicity.

Details

Language :
English
ISSN :
15237060
Database :
OpenAIRE
Journal :
Organic Letters, Vol. 19, No 3 (2017) pp. 612-615
Accession number :
edsair.doi.dedup.....499374aa90a4159699fff4c66596e28f