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Myosin Light Chain 9/12 Regulates the Pathogenesis of Inflammatory Bowel Disease

Authors :
Masaya Yokoyama
Motoko Y. Kimura
Toshihiro Ito
Koji Hayashizaki
Yukihiro Endo
Yangsong Wang
Ryoji Yagi
Tomoo Nakagawa
Naoya Kato
Hisahiro Matsubara
Toshinori Nakayama
Source :
Frontiers in Immunology, Frontiers in Immunology, Vol 11 (2021)
Publication Year :
2021
Publisher :
Frontiers Media SA, 2021.

Abstract

The numbers of patients with inflammatory bowel disease (IBD), such as ulcerative colitis (UC) and Crohn’s disease (CD), have been increasing over time, worldwide; however, the pathogenesis of IBD is multifactorial and has not been fully understood. Myosin light chain 9 and 12a and 12b (Myl9/12) are known as ligands of the CD69 molecule. They create “Myl9 nets” that are often detected in inflamed site, which play a crucial role in regulating the recruitment and retention of CD69-expressing effector cells in inflamed tissues. We demonstrated the strong expression of Myl9/12 in the inflamed gut of IBD patients and mice with DSS-induced colitis. The administration of anti-Myl9/12 Ab to mice with DSS-induced colitis ameliorated the inflammation and prolonged their survival. The plasma Myl9 levels in the patients with active UC and CD were significantly higher than those in patients with disease remission, and may depict the disease severity of IBD patients, especially those with UC. Thus, our results indicate that Myl9/12 are involved in the pathogenesis of IBD, and are likely to be a new therapeutic target for patients suffering from IBD.

Details

ISSN :
16643224
Volume :
11
Database :
OpenAIRE
Journal :
Frontiers in Immunology
Accession number :
edsair.doi.dedup.....49939f9986bbb30d9857da0818915b5f
Full Text :
https://doi.org/10.3389/fimmu.2020.594297