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Myosin Light Chain 9/12 Regulates the Pathogenesis of Inflammatory Bowel Disease
- Source :
- Frontiers in Immunology, Frontiers in Immunology, Vol 11 (2021)
- Publication Year :
- 2021
- Publisher :
- Frontiers Media SA, 2021.
-
Abstract
- The numbers of patients with inflammatory bowel disease (IBD), such as ulcerative colitis (UC) and Crohn’s disease (CD), have been increasing over time, worldwide; however, the pathogenesis of IBD is multifactorial and has not been fully understood. Myosin light chain 9 and 12a and 12b (Myl9/12) are known as ligands of the CD69 molecule. They create “Myl9 nets” that are often detected in inflamed site, which play a crucial role in regulating the recruitment and retention of CD69-expressing effector cells in inflamed tissues. We demonstrated the strong expression of Myl9/12 in the inflamed gut of IBD patients and mice with DSS-induced colitis. The administration of anti-Myl9/12 Ab to mice with DSS-induced colitis ameliorated the inflammation and prolonged their survival. The plasma Myl9 levels in the patients with active UC and CD were significantly higher than those in patients with disease remission, and may depict the disease severity of IBD patients, especially those with UC. Thus, our results indicate that Myl9/12 are involved in the pathogenesis of IBD, and are likely to be a new therapeutic target for patients suffering from IBD.
- Subjects :
- Male
Crohn’s disease
0301 basic medicine
Gene Expression
Inflammatory bowel disease
Pathogenesis
Mice
0302 clinical medicine
Myl9
Immunology and Allergy
Molecular Targeted Therapy
Intestinal Mucosa
Original Research
Crohn's disease
Antibodies, Monoclonal
plasma biomarker
Middle Aged
Immunohistochemistry
Ulcerative colitis
Female
030211 gastroenterology & hepatology
Disease Susceptibility
medicine.symptom
lcsh:Immunologic diseases. Allergy
Adult
Myosin Light Chains
Myosin light-chain kinase
Immunology
Enzyme-Linked Immunosorbent Assay
Inflammation
digestive system
Diagnosis, Differential
03 medical and health sciences
medicine
Animals
Humans
Colitis
CD69
Aged
ulcerative colitis
business.industry
Inflammatory Bowel Diseases
medicine.disease
digestive system diseases
Disease Models, Animal
030104 developmental biology
Case-Control Studies
MYL9
lcsh:RC581-607
business
Biomarkers
Subjects
Details
- ISSN :
- 16643224
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Frontiers in Immunology
- Accession number :
- edsair.doi.dedup.....49939f9986bbb30d9857da0818915b5f
- Full Text :
- https://doi.org/10.3389/fimmu.2020.594297