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The antiobese effect of AT1 receptor blockade is augmented in mice lacking Mas
- Source :
- Naunyn-Schmiedeberg's Archives of Pharmacology. 392:865-877
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- We recently showed that the antiobese efficacy of the AT1 receptor blocker telmisartan (TEL) is at least partially related to an Ang(1-7)-dependent mechanism. Ang(1-7) acts via Mas, thus raising the question of whether Mas-deficient (Mas-ko) mice are likewise predisposed to develop diet-induced obesity and, further, whether this can be prevented by TEL treatment. Mas-ko mice and FVB/N wild-type (wt) animals were treated with TEL (8 mg/kg/day) or vehicle while they were fed with high-fat diet (HFD) or chow. Mice were phenotyped regarding body weight, fat mass, insulin sensitivity, and leptin sensitivity. In response to HFD feeding, gain in body weight and impairment of leptin sensitivity were similar between wt and Mas-ko mice. TEL reduced body weight in both strains but effects were stronger in Mas-ko mice. TEL diminished fat mass and restored leptin sensitivity only in Mas-ko mice. Blood glucose was higher in wt than Mas-ko mice fed with HFD while not differing when they were fed with chow. Insulin challenge confirmed that wt mice became insulin resistant when fed with HFD while HFD feeding did not impair insulin sensitivity in Mas-ko mice. TEL had no further effect. Our findings on the influence of TEL on growth and metabolism in Mas-ko mice conflict with our previous findings in rats. We assume that the FVB/N background of the mice may partly explain these inconsistent data. Moreover, it also seems feasible that the MrgD receptor compensates for Mas deficiency.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
medicine.medical_treatment
030204 cardiovascular system & hematology
Diet, High-Fat
Proto-Oncogene Mas
Receptor, Angiotensin, Type 1
Receptors, G-Protein-Coupled
03 medical and health sciences
0302 clinical medicine
Proto-Oncogene Proteins
hemic and lymphatic diseases
Internal medicine
Renin–angiotensin system
medicine
Animals
Obesity
Telmisartan
Receptor
Mice, Knockout
Pharmacology
Angiotensin II receptor type 1
business.industry
Leptin
Insulin
Body Weight
digestive, oral, and skin physiology
General Medicine
Metabolism
medicine.disease
030104 developmental biology
Endocrinology
Anti-Obesity Agents
business
Angiotensin II Type 1 Receptor Blockers
hormones, hormone substitutes, and hormone antagonists
medicine.drug
Subjects
Details
- ISSN :
- 14321912 and 00281298
- Volume :
- 392
- Database :
- OpenAIRE
- Journal :
- Naunyn-Schmiedeberg's Archives of Pharmacology
- Accession number :
- edsair.doi.dedup.....49a65532d3cbbf91ee8315b72502dc14
- Full Text :
- https://doi.org/10.1007/s00210-019-01643-0